Chelation Assignments of GaⅢ, GeⅣ and SiⅣ Metal Ions With Pipemidic Acid Antibiotic Drug: Synthesis, Spectroscopic Characterizations and Biological Studies

doi:10.3964/j.issn.1000-0593(2020)10-3303-06

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Abstract Pipemidic acid is one of an efficient quinolone antibacterial drug. Thecomplexitybetween pipemidic acid “Hpipc” withgallium(Ⅲ), germanium(Ⅳ) and silicon(Ⅳ) afforded three molecular formulas of [Ga(pipc)₂(H₂O)(Cl)]·4H₂O, 1, [Ge(pipc)₂(Cl)₂]·4H₂O, 2 and[Si(pipc)₂(Cl)₂]·4H₂O, 3 complexes. These three new complexes were characterized based on elemental analysis, conductance, FTIR, UV-Vis, ¹HNMR and XRD spectroscopy. The pipc chelate exhibits O, O coordinated through the carbonyl (C═O) and carboxylato (COO) of both oxygen atoms. Six coordinate geometry was proposed regarding complexes of 2 and 3, so the axial position was occupied by two coordinated chlorideatoms. In vitro, the antibacterial, antifungal, and anti-cancer assessments concerning the synthesized pipc complexes were scanned. These complexes have an excellent anti-microbial activity.

Key words：Pipemidic; Metal ions; Chelation; FTIR; XRD; Biological activity

Received: 2020-01-17 Accepted: 2020-05-06

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O433.5

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http://www.gpxygpfx.com/EN/10.3964/j.issn.1000-0593(2020)10-3303-06 OR http://www.gpxygpfx.com/EN/Y2020/V40/I10/3303

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