|
|
|
|
|
|
Sandwich Terahertz Microfluidic Chip |
FAN Ning, SU Bo*, WU Ya-xiong, ZHANG Hong-fei, ZHANG Cong, ZHANG Sheng-bo, ZHANG Cun-lin |
Key Laboratory of Terahertz Optoelectronics, Ministry of Education; Beijing Key Laboratory for Terahertz Spectroscopy and Imaging; Beijing Advanced Innovation Center for Imaging Technology, Department of Physics, Capital Normal University, Beijing 100048, China |
|
|
Abstract The vibrational and rotational model of many biological macromolecules fall in the THz range, so THz can be used for the qualitative identification of samples. It is well known that the activity of most biomolecules can be expressed in aqueous solution. However, water, as a polar substance, has a strong absorption to THz. Therefore, many measures are adopted to reduce the impact of water for getting more information of biological samples in liquid environment. In this paper, we designed two kinds of PDMS-based sandwich microfluidic chips, which couldreduce the absorption of THz by means of micro channel. Thereforea higher THz transmission of sampleswas achieved through the terahertz time-domain spectroscopy (THz-TDS) system. The material of Zeonor 1420r wasused as substrate and cover plate, and the PDMS as channel interlayer. The transmission of the empty microfluidic chip is more than 80% in the range of 0.2~2.6 THz by THz-TDS system. Then the THz spectra of deionized water and 1,2-propanediol with different concentrations in the microfluidic chip weremeasured, respectively. The results indicatethat the THz transmission of mixtures with different volume ratios has obvious difference. The feasibility of the chip to measure liquid samples has beenproved. In addition, the solutions of potassium chloride and potassium iodide with different concentrations were detected by using the microfluidic chip, and the results show that the transmittance of THz decreases with the increase of the concentration of potassium chloride solution, while the potassium iodide solution has the reverse result. It is found that the electrolyte changes the hydrogen bond density in the aqueous solution, which leads to the change of THz absorption in solution.
|
Received: 2017-05-02
Accepted: 2017-09-30
|
|
Corresponding Authors:
SU Bo
E-mail: su-b@163.com
|
|
[1] Gallerano G P, Doria A, Giovenale E, et al. Journal of Infrared, Millimeter, and Terahertz Waves, 2014, 35(1): 17.
[2] WU Ying, SU Bo, FAN Ning, et al(吴 英, 苏 波, 范 宁, 等). Actc Photonica Sinica(光子学报), 2016, 45(7): 0730003.
[3] Bennett D B, Taylor Z D, Tewari P, et al. Journal of Biomedical Optics, 2012, 17(9): 97008.
[4] Shiraga K, Ogawa Y, Kondo N, et al. Food Chem., 2013, 140(1-2): 315.
[5] Tzu-Fang Tseng, Szu-Chi Yang, Yuan-Ta Shih, et al. Optics Express, 2015, 23(19): 25058.
[6] YANG Chen, TIAN Lu, ZHAO Kun(杨 晨, 田 璐, 赵 昆). Actc Photonica Sinica(光子学报), 2012, 41(5): 627.
[7] Globus T, Moyer A, Gelmont B, et al. Terahertz Physics, Devices, and Systems VU: Advanced Applications in Industry and Defense, 2013. 8716.
[8] YANG Jing-qi, LI Shao-xian, ZHAO Hong-wei, et al(杨静琪, 李绍限, 赵红卫, 等). Acta Physica Sinica(物理学报), 2014, 63(13): 1332031.
[9] George P A, Hui W, Rana F, et al. Optics Express, 2008, 16: 1577.
[10] Fan Fei, Gu Wenhao, Wang Xianghui, et al. Appl. Phys. Lett., 2013, 102(12): 121113.
[11] Zhang Mingkun, Yang Zhongbo, Tang Mingjie, et al. IEEE 3M-NANO 2016-6<sup>th</sup>, 2016.
[12] Shen D X, Zhang C Q, Luo Z Z, et al. Micronanoelectronic Technology Z1, 2003. 369.
[13] Zheng Z P, Fan W H, Li H, et al. J. Mol. Spectrosc., 2014, 296(4): 9.
[14] WANG Wen-hua, ZHAO Lin, YAN Bo(王文华, 赵 林, 阎 波). Chemistry(化学通报), 2010,(6): 491.
[15] ZHANG Bin, CHEN Jian-hong, JIAO Ming-xing(张 彬, 陈剑虹, 焦明星). Spectroscopy and Spectral Analysis(光谱学与光谱分析), 2015, 35(7): 1840. |
[1] |
WAN Mei, ZHANG Jia-le, FANG Ji-yuan, LIU Jian-jun, HONG Zhi, DU Yong*. Terahertz Spectroscopy and DFT Calculations of Isonicotinamide-Glutaric Acid-Pyrazinamide Ternary Cocrystal[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(12): 3781-3787. |
[2] |
WU Jing-zhi1, 2, ZHOU Si-cheng3, JI Bao-qing1, WANG Yan-hong1, 2*, LI Meng-wei2, 3. Porosity Measurement of Tablets Based on Continuous Terahertz Wave[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(11): 3360-3364. |
[3] |
MU Da1, 2, WANG Qi-shu1, 2*, CUI Zong-yu1, 2, REN Jiao-jiao1, 2, ZHANG Dan-dan1, 2, LI Li-juan1, 2, XIN Yin-jie1, 2, ZHOU Tong-yu3. Study on Interference Phenomenon in Terahertz Time Domain
Spectroscopy Nondestructive Testing of Glass Fiber Composites[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(10): 3031-3040. |
[4] |
LI Yang1, LI Xiao-qi1, YANG Jia-ying1, SUN Li-juan2, CHEN Yuan-yuan1, YU Le1, WU Jing-zhu1*. Visualisation of Starch Distribution in Corn Seeds Based on Terahertz Time-Domain Spectral Reflection Imaging Technology[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(09): 2722-2728. |
[5] |
YU Yang1, ZHANG Zhao-hui1, 2*, ZHAO Xiao-yan1, ZHANG Tian-yao1, LI Ying1, LI Xing-yue1, WU Xian-hao1. Effects of Concave Surface Morphology on the Terahertz Transmission Spectra[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(09): 2843-2848. |
[6] |
ZHENG Zhi-jie1, LIN Zhen-heng1, 2*, XIE Hai-he2, NIE Yong-zhong3. The Method of Terahertz Spectral Classification and Identification for Engineering Plastics Based on Convolutional Neural Network[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(05): 1387-1393. |
[7] |
LIU Hong-yuan1, WU Bin1, 2, JIANG Tao3, YANG Yan-zhao1, WANG Hong-chao1, LI Jing-song1. Study on the Measurement of Absolute Spectral Responsivity of Terahertz Detector[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(04): 1017-1022. |
[8] |
WANG Yu-ye1, 2, LI Hai-bin1, 2, JIANG Bo-zhou1, 2, GE Mei-lan1, 2, CHEN Tu-nan3, FENG Hua3, WU Bin4ZHU Jun-feng4, XU De-gang1, 2, YAO Jian-quan1, 2. Terahertz Spectroscopic Early Diagnosis of Cerebral Ischemia in Rats[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(03): 788-794. |
[9] |
CHU Zhi-hong1, 2, ZHANG Yi-zhu2, QU Qiu-hong3, ZHAO Jin-wu1, 2, HE Ming-xia1, 2*. Terahertz Spectral Imaging With High Spatial Resolution and High
Visibility[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(02): 356-362. |
[10] |
LI Qing-jun, SHEN Yan, MENG Qing-hao, WANG Guo-yang, YE Ping, SU Bo*, ZHANG Cun-lin. Terahertz Absorption Characteristics of Potassium Salt Solution Based on Microfluidic Chip[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(02): 363-367. |
[11] |
ZHANG Tian-yao1, 2, LI Bo-yang1, LI Xing-yue1, LI Ying1, WU Xian-hao1, ZHAO Xiao-yan1, ZHANG Zhao-hui1*. Refractive Index Measurement Using Continuous Wave Terahertz
Frequency-Domain Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(02): 495-502. |
[12] |
LU Xue-jing1, 2, GE Hong-yi2, 3, JIANG Yu-ying2, 3, ZHANG Yuan3*. Application Progress of Terahertz Technology in Agriculture Detection[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(11): 3330-3335. |
[13] |
ZHAO Xin-yuan, WANG Guo-yang, MENG Qing-hao, ZHANG Feng-xuan, SHAO Si-yu, DING Jing, SU Bo*, ZHANG Cun-lin. Terahertz Transmission Characteristics of Magneto-Fluidic Carrier Liquid Based on Microfluidic Technology[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(10): 3012-3016. |
[14] |
CAO Yu-qi2, KANG Xu-sheng1, 2*, CHEN Piao-yun2, XIE Chen2, YU Jie2*, HUANG Ping-jie2, HOU Di-bo2, ZHANG Guang-xin2. Research on Discrimination Method of Absorption Peak in Terahertz
Regime[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(10): 3058-3062. |
[15] |
WANG Guo-yang,MENG Qing-hao,SHAO Si-yu,YE Ping,SU Bo*,ZHANG Cun-lin. Terahertz Absorption Characteristics of Low Temperature Liquid Water[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(09): 2709-2713. |
|
|
|
|