Preparation and Characterization of Silicon, Silver, Fluorine Co-Modified Hydroxyapatite Nano-Biofilms
YE Ting1, QIAO Hai-xia1, HUANG Yong1,2*, GUO Jia-chi1, MA Meng-chu1, RU Ping1, CHEN Fang-fang1, YUAN Cui-fang1, LIU Huan1, SU Zhuo-bin3, ZHANG Xue-jiao1*, GAO Yuan4
1. College of Lab Medicine, Hebei North University, Zhangjiakou 075000, China
2. Institute of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China
3. First Affiliated Hospital, Hebei North University, Zhangjiakou 075000, China
4. Department of Electronic and Computer Engineering, Hong Kong University of Science, Hong Kong S.A.R, China
Abstract：In this study, a novel silicon, silver, fluorine co-modified hydroxyapatite (Si-Ag-F-HA) nano-biofilms was deposited on CP-Ti through electrodeposition. Ag was incorporated into HA coating to improve the antimicrobial properties. Si was added as a second binary element to offset the potential cytotoxicity of Ag. The as-prepared coatings were examined by scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) tests. Results highlight that F-, Si4+ and Ag+ could be evenly incorporated into the Si-Ag-F-HA coating. The results indicate that the Si-Ag-F-HA coatings take the morphology of nanoscale- villous-like，the composite coating becomes more compact. The composite coatings were found to be bioactive, based on the promotion of additional apatite onto the Si-Ag-F-HA coating surface from SBF. Potentiodynamic polarisation tests revealed that the corrosion resistance increased after Si-Ag-F-HA coating. The release of Si and Ag ions from Si-Ag-F-HA coatings shows sustained release kinetics without burst release, which reached a near steady state afterwards, thereby revealing long-term sustainable release. FTIR and ICP-MS provide a rapid and effective method for the development of new antibacterial hard tissue repair materials.
[1] Bakhsheshi-Rad H R, Hamzah E, Ismail A F, et al. Ceram. Int., 2016, 42：11941.
[2] ZHANG Xue-jiao, HAO Min, QIAO Hai-xia, et al(张雪姣, 郝 敏, 乔海霞，等). Spectroscopy and Spectral Analysis(光谱学与光谱分析), 2016, 36(3): 686.
[3] Lim P N, Shi Z L, Neoh K G, et al. Biomed. Mater., 2014, 9：1.
[4] Shirazi S F S, Gharehkhani S, Metselaar H S C, et al, RSC. Adv., 2016, 6：190.
[5] Huang Y, Qiao H X, Nian X F, et al. Surf. Coat. Tech., 2016, 291: 205.
[6] Huang Y, Zhang X J, Qiao H X, et al. Ceram. Int., 2016, 42: 1903.
[7] Huang Y, Zhang H L, Qiao H X, et al. Appl. Surf. Sci., 2015, 357: 1776.
[8] Huang Y, Zhang X J, Mao H H, et al. RSC. Adv., 2015, 5: 17076.
[9] Vranceanu D M, Cotrut C M, Bramowicz M, et al, Ceram. Int., 2016, 42: 10085.
[10] Ando Y, Miyamoto H, Noda I, et al, Mater. Sci. Eng. C, 2010, 30：175.
[11] Gopi D, Shinyjoy E, Kavitha L. Spectrochimica Acta Part A, Molecular and Biomolecular Spectroscopy, 2014, 127.
[12] Dong G, Zheng Y X, He L Y, et al. Ceram. Int., 2016, 42: 883.
