Study on Cephalosporins with Terahertz Time-Domain Spectroscopy Technique
ZHANG Man, ZHU Si-yuan, LI Qing-mei, SHEN Jing-ling*
Beijing Key Laboratory for Terahertz Spectroscopy and Imaging, Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Department of Physics, Capital Normal University, Beijing 100048, China
Abstract：Terahertz Time-Domain Spectroscopy (THz-TDS) technique has a wide range of applications in substances identification and quantitative analysis. In the present paper, we report absorption spectra and index of refraction of 14 kinds of pure cephalosporins in 0.2～2.6 THz, in which eight kinds have apparent absorption peaks, while the others have different index of refraction. Based on these results, different kinds of antibiotics can be identified. Besides, according to THz absorption spectra of both pure sample and real pills we calculated the contents of cefixime in the two pills produced by two manufacturers. Compared with the contents marked on the package, relative errors are 9.38% and 0.92%, respectively. The results manifest that THz-TDS technique is reliable and promising in medicine detection.
Key words：Cephalosporins;Terahertz time-domain spectroscopy technique;Absorption;Index of refractive;Content calculation of cefixime
[1] Philip C Ashworth, Emma Pickwell-MacPherson, Elena Provenzano, et al. Opt. Exp., 2009, 17: 12444. [2] Markus Walther, Bernd M Fischer, Alex Ortner, et al. Anal. Bioanal. Chem., 2010, 397: 1009. [3] SUN Jin-hai, SHEN Jing-ling, LIANG Lai-shun, et al((孙金海，沈京玲，梁来顺，等). Chin. Phys. Lett.(中国物理快报), 2005, 22: 3176. [4] LI Ning, SHEN Jing-ling, SUN Jin-hai, et al(李 宁，沈京玲，孙金海，等). Opt. Exp., 2005, 13: 6750. [5] Abraham E, Younus A, Delagnes J C, et al. Appl. Phys. A, 2010, 10: 1007. [6] LIANG Mei-yan, SHEN Jing-ling, WANG Guang-qin(梁美妍，沈京玲，王光琴). J. Phys. D: Appl. Phys., 2008, 41: 135306. [7] Wu Q, Zhang X C, Opt. Quant. Electron., 1996, 28: 945. [8] Markelz A G, Roitberg A, Heilweil E J. Chem. Phys. Lett. , 2000, 320: 42. [9] Zeitler J A, Taday P F, Newnham D A, et al. J. Pharm. Pharmacol., 2007, 59: 209. [10] LIU Xiao-hong, ZHAO Hong-wei, LIU Gui-feng，et al(刘晓鸿，赵红卫，刘桂锋, 等). Prog. Chem.(化学进展), 2010, 11: 2191. [11] JIN Biao-bin, ZHANG Cun-lin, WU Pei-hong, et al(金标斌，张存林，吴佩宏, 等). Terahertz Science and Technology, 2010, 3: 192. [12] Duvillaret Lionel, Garet Frederric, Coutaz Jean-Louis. IEEE J. Selected Topic in Quantum Electronics, 1996, 2: 793. [13] Duvillaret Lionel, Garet Frederric, Coutaz Jean-Louis. Appl. Opt., 1998, 38: 409. [14] Dorney Timothy D, Baraniuk Richard G, Mittleman Daniel M. J. Opt. Soc. Am. A, 2001, 18: 1562. [15] Jiang Dejun, Zhao Shusen，Shen Jingling. Proc. of SPIE, 2007, 6840 68400U：1.
