Non-Invasive Measurement of Human Blood Cholesterol Concentration Based on Dynamic Spectrum Method
SUO Yong-kuan1,2, LI Gang2, WANG Hui-quan2, LIN Ling2
1. Biomedical Engineering, China Medical University,Shenyang 110001, China 2. State Key Laboratory of Precision Measuring Technology and Instruments,Tianjin University,Tianjin 300072,China
Abstract:For non-invasive measurement of human blood cholesterol concentration, this experiment was carried out on 80 volunteers clinically. In vivo dynamic spectra of fingers were achieved and biochemical examinations of blood components contents including cholesterol were get as soon as possible. BP artificial neural network with inputs of dynamic spectra plus energy of harmonic waves processed by Principal Components Analysis(PCA) was used to establish the model of the total cholesterol values. The correlation between the predicted value and the true value of cholesterol is 96.48%. The maximum relative error is 25.44% and root-mean-square error of prediction is 0.242 6 mmol·L-1. The results show that PCA can make the process of computing faster and this study is another advance of dynamic spectra.
索永宽1,2,李 刚2,王慧泉2,林 凌2 . 基于动态光谱法的人体血液胆固醇含量无创检测[J]. 光谱学与光谱分析, 2012, 32(01): 188-191.
SUO Yong-kuan1,2, LI Gang2, WANG Hui-quan2, LIN Ling2 . Non-Invasive Measurement of Human Blood Cholesterol Concentration Based on Dynamic Spectrum Method . SPECTROSCOPY AND SPECTRAL ANALYSIS, 2012, 32(01): 188-191.
[1] Stapleton P A, Goodwill A G, James M E, et al. Journal of Inflammation-London, 2010, 7(54): 10. [2] Thompson G R, Catapano A, Saheb S, et al. Current Opinion in Lipidology, 2010, 21(6): 492. [3] Akikazu Sakudo, Yukiko Hakariya Kato, Hirohiko Kuratsune, et al. Clinica Chimica Acta,2009,408:123. [4] Marcel Mueller, Michael Grunze, Edward H Leiter, et al. Sensors and Actuators B,2009,142:502. [5] Adelina Pellicer, María del Carmen Bravo. Seminars in Fetal & Neonatal Medicine,2011,16:42. [6] LUO Yun-han(罗云瀚). Laser & Infrared(激光与红外), 2008, 38(5): 465. [7] LIU Rong, XU Ke-xin(刘 蓉, 徐可欣). Journal of Tianjin University(天津大学学报), 2008, 41(1): 1. [8] Xu Kexin, Lu Yanhui, Li Qingbo, et al. Proc. SPIE Int. Soc. Opt. Eng., 2004, 5486: 100. [9] Li Gang, Liu Yu-liang, Lin Ling, et al. 3rd International Symposium on Instrumentation Science and Technology, Xi’an, China , 2004, 3:0875. [10] LI Gang,WANG Yan,LI Qiu-xia,et al(李 刚, 王 焱, 李秋霞, 等). J. Infrared Millim. Waves(红外与毫米波学报), 2006, 25:345. [11] LI Gang, MEN Jian-long, SUN Zhao-min, et al(李 刚, 门剑龙, 孙兆敏, 等). Journal of Tianjin University(天津大学学报), 2011, 44(1):90. [12] Wang Jin, Chen Yu, Adjouadi Malek. IEEE Applied Imagery Pattern Recognition Workshop, 2008, 37:1. [13] Gmez P, Daz F, Lvarez A, et al. 18th IEEE Symposium on Computer-Based Medical Systems (CBMS’05), 2005. 41. [14] LAN Xiu-feng, LIU Ying,ZHU Tuo, et al(蓝秀凤,刘 莹,朱 拓,等). Acta Photonica Sinica(光子学报), 2008, 37(3), 547.