Determination of Trace BrO-3 and Br- in Chinese Patent Drugs, Waters and Beverages by Ion Chromatography Coupled with Inductively Coupled Plasma Mass Spectrometry
LI Ji-chao1, WANG Xiao-yan1, OUYANG Li1, ZENG Jing1, YAN Lai-lai1, CHEN Shun-zong2, WU Yan-wen2, WANG Jing-yu1，3*
1. School of Public Health, Peking University, Beijing 100191, China 2. Beijing Center for Physical & Chemical Analysis, Beijing 100089, China 3. Center of Medical & Health Analysis, Peking University, Beijing 100191, China
Abstract：In the present study, a method for determination of BrO-3 and Br- using ion chromatograghy coupling with inductively coupled plasma mass spectrometry (IC-ICP-MS) was developed. BrO-3 and Br- were separated on a Hamilton PRP X-100(150×4.1 mm, 10 μm)column guarding with a On-guard Ⅱ RP(4×50 mm)column with 10 mmol·L-1 NH4NO3 eluent solution at 2 mL·min-1. By using 200 μL sample loop, the detection limits for BrO-3 and Br- were 0.35 and 0.36 μg·L-1, respectively. BrO-3 had good linearity in the range 4.8 -160.0 ng·L-1. The standard solution linear equation was y=250.31x-45.43, and R2=0.999 9. Br- had good linearity in the range 4.2-140.0 ng·L-1. The standard solution linear equation was y=186.84x-127.10, and R2=0.999 4. Recoveries of spiked samples were 98.9%-109.5% and 97.4%-106.1%, respectively. The samples included various kinds of Chinese patent drugs, waters, and beverages. Among them, 14 bottled drinking waters and 2 kinds of tap waters were found containing BrO-3, while other samples were under BrO-3 detection limit. Br- was detected in all samples.
Key words：IC;ICP-MS;Chinese patent drug;Water and beverage;BrO-3;Br-
李骥超1，王小燕1，欧阳荔1，曾 静1，闫赖赖1，陈瞬宗2，武彦文2，王京宇1，3*. 离子色谱-电感耦合等离子体质谱联用测定中成药，水体及饮料中痕量BrO-3及Br-[J]. 光谱学与光谱分析, 2010, 30(11): 3136-3139.
LI Ji-chao1, WANG Xiao-yan1, OUYANG Li1, ZENG Jing1, YAN Lai-lai1, CHEN Shun-zong2, WU Yan-wen2, WANG Jing-yu1，3*. Determination of Trace BrO-3 and Br- in Chinese Patent Drugs, Waters and Beverages by Ion Chromatography Coupled with Inductively Coupled Plasma Mass Spectrometry. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2010, 30(11): 3136-3139.
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