Spectroscopic Investigations for the Six New Synthesized Complexes of Fluoroquinolones and Quinolones Drugs With Nickel(Ⅱ) Metal Ion: Infrared and Electronic Spectroscopy
Samar O. Aljazzar
Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia
Spectroscopic Investigations for the Six New Synthesized Complexes of Fluoroquinolones and Quinolones Drugs With Nickel(Ⅱ) Metal Ion: Infrared and Electronic Spectroscopy
Samar O. Aljazzar
Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia
摘要： Quinolone has a broad spectrum of synthetic antibiotics with a strong therapeutic effect and quinolone is a term used for chemical treatments used to treat a powerful bacteria. Quinolones are divided into 4 generations according to the bacterial spectrum, the majority of quinolones used clinically belong to the sub fluoroquinolones group, which has a fluorine atom linked to the central ring system, usually on its carbon atom 6 or 7. Herein in this article, six new nickel(Ⅱ) complexes (Ⅰ—Ⅵ) have been synthesized in aqueous alkaline media at pH ranged 8-9, the chemical reactions take place between levofloxacin (HLEV), lomefloxacin (HLOM), nalidixic acid (HNLA), oxolonic acid (HOXO), pipemidic acid (HPIP), and pefloxacin mesylate (HPEF) with nickel(Ⅱ) nitrate hexahydrate. The microanalytical (percentage of carbon, hydrogen and nitrogen), molar conductance (Λm), Infrared (FTIR) spectra, electronic (UV-Vis) spectra, and effective magnetic moment instrumentals were used to identify the suggested structures and their surface morphology. According the analytical and spectroscopic analyses, the stoichiometry between nickel(Ⅱ) metal ion and drug ligands was found to be 1∶2 with general formula as [Ni(L)2(H2O)2]·xH2O (L=LEV (Ⅰ), LOM (Ⅱ), NAL (Ⅲ), OXO (Ⅳ), PIP (V), and PEF (Ⅵ); x=2 or 4). By the comparison between FTIR spectra of quinolone drugs and their complexes, it can be deduced that all the drug ligands act as a bidentate chelates through oxygen atoms of pyridine ring and carboxylate group. The electronic configuration of all synthesized nickel(Ⅱ) complexes were octahedral geometry which confirmed based on the values of magnetic susceptibility and the electronic transition bands.
Abstract：Quinolone has a broad spectrum of synthetic antibiotics with a strong therapeutic effect and quinolone is a term used for chemical treatments used to treat a powerful bacteria. Quinolones are divided into 4 generations according to the bacterial spectrum, the majority of quinolones used clinically belong to the sub fluoroquinolones group, which has a fluorine atom linked to the central ring system, usually on its carbon atom 6 or 7. Herein in this article, six new nickel(Ⅱ) complexes (Ⅰ—Ⅵ) have been synthesized in aqueous alkaline media at pH ranged 8-9, the chemical reactions take place between levofloxacin (HLEV), lomefloxacin (HLOM), nalidixic acid (HNLA), oxolonic acid (HOXO), pipemidic acid (HPIP), and pefloxacin mesylate (HPEF) with nickel(Ⅱ) nitrate hexahydrate. The microanalytical (percentage of carbon, hydrogen and nitrogen), molar conductance (Λm), Infrared (FTIR) spectra, electronic (UV-Vis) spectra, and effective magnetic moment instrumentals were used to identify the suggested structures and their surface morphology. According the analytical and spectroscopic analyses, the stoichiometry between nickel(Ⅱ) metal ion and drug ligands was found to be 1∶2 with general formula as [Ni(L)2(H2O)2]·xH2O (L=LEV (Ⅰ), LOM (Ⅱ), NAL (Ⅲ), OXO (Ⅳ), PIP (V), and PEF (Ⅵ); x=2 or 4). By the comparison between FTIR spectra of quinolone drugs and their complexes, it can be deduced that all the drug ligands act as a bidentate chelates through oxygen atoms of pyridine ring and carboxylate group. The electronic configuration of all synthesized nickel(Ⅱ) complexes were octahedral geometry which confirmed based on the values of magnetic susceptibility and the electronic transition bands.
基金资助: the deanship of scientific Research at Princess Nourah bint Abdulrahman University through the Fast-track Research Funding program
作者简介: drsamaraljazzar2020@gmail.com
引用本文:
Samar O. Aljazzar. Spectroscopic Investigations for the Six New Synthesized Complexes of Fluoroquinolones and Quinolones Drugs With Nickel(Ⅱ) Metal Ion: Infrared and Electronic Spectroscopy[J]. 光谱学与光谱分析, 2021, 41(06): 1976-1981.
Samar O. Aljazzar. Spectroscopic Investigations for the Six New Synthesized Complexes of Fluoroquinolones and Quinolones Drugs With Nickel(Ⅱ) Metal Ion: Infrared and Electronic Spectroscopy. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(06): 1976-1981.
[1] Emami S, Shahrokhirad N, Foroumadi A, et al. Med. Chem. Res., 2013, 22: 5940.
[2] Von Rosenstiel N, Adam D. Drugs, 1994, 47(6): 872.
[3] Sultana N, Arayne M S, Rizvi S B S, et al. Med. Chem. Res., 2013, 22: 1371.
[4] Tarushi A, Polatoglou E, Kljun J, et al. Dalton Trans., 2011, 40: 9461.
[5] Vieira L M M, de-Almeida M V, Lourenço M C S, et al. Eur. J. Med. Chem.，2009, 44: 4107.
[6] Patel M N, Gandhi D S, Parmar P A. Inorg. Chem. Commun., 2012, 15: 248.
[7] Gouvea L R, Garcia L S, Lachter D R, et al. Eur. J. Med. Chem.，2012，55：67.
[8] Siji V L, Sudarsana Kumar M R, Suma S, et al. Spectrochim. Acta A, 2010, 76: 22.
[9] Sadeek S A, El-Shwiniy W H. J. Mol. Struct., 2010, 98: 130.
[10] Abd El-Halim H F, Mohamed G G, El-Dessouky M M I, et al. Spectrochim. Acta A, 2011，82：8.
[11] Qi W, Huang J, An Z. Acta Crystallogr., 2008, 64: m302.
[12] Zaky M, El-Sayed M Y, El-Megharbel S M, et al. Russ. J. Gen. Chem., 2013, 83(12): 1070.
[13] Al-Khodir F A I, Refat M S. J. Mol. Struct., 2015, 1094: 22.
[14] Debnath A, Mogha N K, Masram T D. Appl. Biochem. Biotechnology, 2015，175(5)：2659.
[15] Behrens N B, Diaz G M, Goodgame D M L. Inorg. Chim. Acta, 1986，125(1)：21.
[16] Psomas G, Tarushi A, Efthimiadou E K, et al. J. Inorg. Biochem., 2006, 100: 1764.
[17] Skyrianou K C, Perdih F, Turel I, et al. J. Inorg. Biochem., 2010，104：161.
[18] Tarushi A, Psomas G, Raptopoulou C P, et al. J. Inorg. Biochem., 2009, 103: 898.
[19] Tarushi A, Christofis P, Psomas G. Polyhedron, 2007, 26: 3963.
[20] Tarushi A, Efthimiadou E K, Christofis P, et al. Inorg. Chim. Acta，2007，360：3978.
[21] Efthimiadou E K, Sanakis Y, Katsaros N, et al. Polyhedron, 2007, 26: 1148.
[22] Efthimiadou E K, Katsaros N, Karaliota A, et al. Inorg. Chim. Acta, 2007, 360: 4093.
[23] Skrzypek D, Szymanska B, Kovala-Demertzi D, et al. J. Phys. Chem. Solids, 2006, 67: 2550.
[24] Shaikh A R, Giridhar R, Megraud F, et al. Acta Pharm., 2009，59：259.
[25] Sadeek S A, El-Shwiniy W H. J. Mol. Struct., 2010, 98: 130.
[26] Abd El-Halim H F, Mohamed G G, El-Dessouky M M I, et al. Spectrochim. Acta A, 2011, 82: 8.
[27] Qi W, Huang J, An Z. Acta Crystallogr., 2008, 64: m302.
[28] Drevenšek P, Košmrlj J, Giester G, et al. J. Inorg. Biochem., 2006, 100: 1755.
[29] Geary W J. Coord. Chem. Rev., 1971，7：81.
[30] Nakamoto K. Infrared and Raman Spectra of Inorganic and Coordination Compounds. 4th ed., Wiley, New York, 1986.
[31] Jaffe H H, Orehin M. Theory and Application of Ultraviolet Spectroscopy, John Willey and Sons, New York, 1982; Ismail T M. J. Coord. Chem., 2005，58：141.
[32] Lever A B P. J. Chem. Edu., 1968，45：711.
