Abstract：Purpure-18-imide was synthesized based on the porphyrin’s special affinity for cancer cells and the antitumor activity of pyrrolidine compound. The binding reaction between purpure-18-imide and bovine serum albumins (BSA) in aqueous was studied by fluorescence and UV-Vis absorption spectra. The research results indicated that the combination reaction of them was a single static quenching process. In aqueous, purpure-18-imide strongly bound BSA with molar ratio of 1∶1. The binding constant K０ was 5.386×105 L·mol-1. The shortest binding distance (r=3.54 nm) and energy transfer efficiencies (E=0.26) between donor (BSA) and acceptor (purpure-18-imide ) were obtained by Frster’s nonradiative energy transfer mechanism.
王进军，刘永明，李 利. 紫红素-18-酰亚胺的合成及其对牛血清白蛋白结合作用的荧光法研究 [J]. 光谱学与光谱分析, 2005, 25(04): 594-597.
WANG Jin-jun，LIU Yong-ming, LI Li . Synthesis of Purpure-18-Imide and Study on Its Interaction with Bovine Serum Albumins by Fluorescence . SPECTROSCOPY AND SPECTRAL ANALYSIS, 2005, 25(04): 594-597.
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