AMP-Cu<SUP>2+</SUP>-脱氧胆酸-凝胶体系的时空图案及其结构的研究

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摘要：核苷酸是一类重要的生命物质，在体外模拟胆结石形成的实验中，选取了腺嘌呤核苷酸(AMP)为研究对象，研究了它对Cu²⁺-脱氧胆酸体系形成时空图案的影响，用FTIR表征各种形态沉淀物的结构。结果表明：在AMP存在下的脱氧胆酸-铜离子-凝胶体系中，可形成周期沉淀及分形结构共存的复杂时空图案，红外光谱结果显示其结构中除了脱氧胆酸根(DC^-)与铜离子配位外，AMP也参与了配位，可能形成DC^-1-Cu-AMP的混配型非化学计量的化合物;AMP-脱氧胆酸-葡萄糖-铜凝胶体系的周期沉淀及分形结构中，AMP、葡萄糖、DC与Cu²⁺多核配位作用形成和组成结构更复杂的沉淀。

关键词：胆结石;AMP;周期沉淀;分形;FTIR

Abstract：This is an in vitro model to mimic the conditions present during gallstone formation. Adenosine mono-phosphate (AMP), an important bio-molecule, was chosen. Its effect on the formation of periodic/chaotic patterns in the deoxycholate-CuCl₂-gel and deoxycholate-CuCl₂-glucose-gel systems were studied. FTIR spectroscopy was used to identify the structure of the precipitates. The results indicate that the patterns formed in the systems with AMP are different. And FTIR spectra show that AMP may also be involved in the coordination sphere of Cu²⁺ ion. The results are more complicated in the deoxycholate-CuCl₂ system containing glucose, suggesting that the nonlinear scientific concept should be considered in understanding gallstone formation.

Key words：Gallstone;AMP;Periodic precipitation;Fractal;FTIR

收稿日期: 2004-06-08 修订日期: 2004-09-18

中图分类号:	O614.3
	O657.3

通讯作者: 吴瑾光

引用本文:

尹文萱^{1, 2}, 刘玉峰¹，赵莹³，高庆宇²，吴瑾光^1* . AMP-Cu²⁺-脱氧胆酸-凝胶体系的时空图案及其结构的研究[J]. 光谱学与光谱分析, 2005, 25(06): 930-933.
YIN Wen-xuan^{1, 2}, LIU Yu-feng¹, ZHAO Ying³, GAO Qing-yu², WU Jin-guang^1* . Study on the Structure of Periodic and Chaotic Patterns of AMP-DC-Cu-Gel Systems. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2005, 25(06): 930-933.

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https://www.gpxygpfx.com/CN/Y2005/V25/I06/930