Simultaneous Correction for Blood Matrix Effect on Determination of Magnesium, Copper and Lead Concentration in Blood Samples by ICP-MS Using CAIS
YANG Le1, ZENG Jing1, 2, WANG Xiao-yan1, 2, WU Zan3, CHI Hai-tao3, OUYANG Li1, 2, ZHANG Jing-hua3, WANG Jing-yu1, 2*
1. School of Public Health, Peking University, Beijing 100191, China 2. Laboratory of Biometallomics, Center of Medical & Health Analysis, Peking University, Beijing 100191, China 3. Beijing Centre for Physical & Chemical Analysis, Beijing 100089, China
Abstract：The influence of matrix effect on the determination of magnesium, copper and lead in human blood matrix stimulant and its correction was studied by using both conventional internal reference method & common analyte internal standardization (CAIS). The obtained results indicate that CAIS method is applicable for simultaneous correction of multi-elements in blood matrix. The relative errors between the determined and the true values are 3.05% (by CAIS method), 12.39% (by conventional internal reference correction) and 23.91% (without correction), respectively. Otherwise, the influences of the mass discrepancy and that of the determination intensities between elements are not obvious for the correction of blood matrix. The reliability of CAIS was validated by the determination of both bovine blood and bovine serum standard materials.
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