Non-Invasive Measurement of Human Hemoglobin Concentration by Dynamic Spectrum Method
ZHANG Zhi-yong1, 2, MEN Jian-long1, 3, LI Gang1*, LIN Ling1
1.Tianjin Key Laboratory of Biomedical Detecting Techniques & Instruments, Tianjin University, Tianjin 300072, China 2.Department of Mechanical and Electrical Engineering, Tianjin Agricultural College, Tianjin 300384, China 3.General Hospital of Tianjin Medical University，Tianjin 300052，China
Abstract：For non-invasively measurement of the components of human blood, dynamic spectrum method was used to measure hemoglobin concentration of volunteers for the first time.In-vivo measurements were carried out on 34 healthy volunteers, and their dynamic spectra were collected.To ensure the dynamic spectrum data to be valid, a number of experiments were carried out on the dynamic spectrum data.BP artificial neural network was used to establish the calibration model of subjects’ hemoglobin concentration values against dynamic spectrum data.Among 34 swatches, 19 swatches were taken as calibration set and the other 15 as prediction set.For calibration set and prediction set, the correlation coefficient was 0.983 1 and 0.936 5 respectively.The biggest relative error of prediction is 7.5%, and the average relative error is 3.04%.The accuracy of measurement results can satisfy the demand for clinical application.Measurement results show that the influences of measuring conditions on spectra can be decreased effectively by dynamic spectrum method and this method can be applied to accurate non-invasive measurement of human hemoglobin concentration.It can be a good method for non-invasive blood analysis.
[1] Rosen Noah A, Charash William E, Hirsch Erwin F.Journal of Surgical Research, 2002, 106(2): 282. [2] LUO Qing-ming, DENG Hui, GONG Hui, et al(骆清铭, 邓 晖, 龚 辉, 等).J.Infrared Millim.Waves(红外与毫米波学报), 1999, 18(2): 138. [3] Yamakoshi Y, Ogawa M, Yamakoshi T, et al.Proceedings of the 29th Annual International Conference of the IEEE EMBS, 2007, 23，August, Lyon, France, FrC06.4: 2964. [4] DING Hai-shu, TENG Yi-chao(丁海曙, 腾轶超).Laser & Optoelectronics Progress(激光与光电子学进展), 2007, 44(9): 14. [5] Kye Jin Jeon, Su-Jin Kim，Kun Kook Park.Journal of Biomedical Optics，2002, 7(1): 45. [6] Wuori Edward R, Gmitter Mary B.Proceedings of SPIE-The International Society for Optical Engineering, 2003, 4965: 160. [7] LI Qiu-xia, LI Gang, LIN Ling, et al.Proceeding of the 2005 IEEE Engineering in Medicine and Biology 27th Annual International Conference Shanghai, 2005.1994. [8] LI Gang, WANG Yan, LIN Ling, et al(李 刚，王 焱，林 凌，等).Life Science Insruments(生命科学仪器)，2004，2(5): 33. [9] LI Gang,WANG Yan, LI Qiu-xia, et al(李 刚，王 焱，李秋霞，等).J.Infrared Millim.Waves(红外与毫米波学报), 2006，25: 345. [10] LI Gang，WAN Yan，LI Hai-lan, et al(李 刚，王 焱，李海兰，等).Spectroscopy and Spectral Analysis(光谱学与光谱分析), 2007, 27(10): 1905.
