近红外光谱范围人肝癌变和热凝固导致组织吸收和散射特性的变化

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摘要：研究了人肝的癌变及热凝固导致其对710, 730, 750, 770, 790, 810, 830, 850, 870和890 nm的钛宝石激光的吸收和散射特性的变化，实验采用双积分球测量系统以及反向倍增法获取肝组织的吸收和散射特性参数。结果表明：人肝的癌变导致其吸收系数发生了显著的减小，其变化的最大值在850 nm，其值为86.12%，而变化的最小值在750 nm，其值为82.65%。正常人肝组织热凝固导致其吸收系数明显变化，其吸收系数的变化的最大值在710 nm，其值为79.55%，而变化的最小值在790 nm，其值为0.72%。人肝癌组织热凝固导致其吸收系数显著地增大，其变化的最大值在810 nm，其值为78.69%，而变化的最小值在710 nm，其值为38.16%。人肝的癌变导致了肝组织的散射系数发生了显著的增大，其变化的最大值在710 nm，其值为158.37%，而变化的最小值在890 nm，其值为136.03%。正常人肝组织热凝固导致其散射系数显著地增大，其变化的最大值在890 nm，其值为632.92%，而变化的最小值在710 nm，其值为587.40%。人肝癌组织热凝固导致其散射系数显著地增大，其变化的最大值在810 nm，其值为384.25%，而变化的最小值在710 nm，其值为330.86%。肝组织的吸收和散射特性的变化也随着激光波长的变化而变化。

关键词：人肝组织;吸收和散射特性;钛宝石激光;癌变;热凝固

Abstract：Canceration and thermal coagulation of human liver induced changes in the absorption and scattering properties of liver tissue at 710, 730, 750, 77, 790, 810, 830, 850, 870 and 890 nm of Ti: sapphire laser were studied in vitro. The measurements were performed using a double-integrating-sphere setup, and the absorption and scattering properties were assessed from these measurements using the inverse adding-doubling method. The results of measurement showed that canceration of liver induced significant decrease in the absorption coefficients of liver tissue, and the maximum change in the absorption coefficients is 86.12% at 850 nm, while the minimum change in the absorption coefficients is 82.65% at 750 nm. Thermal coagulation of normal liver induced obvious change in the absorption coefficients from 710 to 890 nm, and the maximum change in the absorption coefficients is 79.55% at 710 nm, while the minimum change in the absorption coefficients 0.72% at 790 nm. Thermal coagulation of carcinoma liver tissue induced significant increase in the absorption coefficients, the maximum change in the absorption coefficients of carcinoma liver tissue is 78.69% at 810 nm, in the minimum change in the absorption coefficients of carcinoma liver tissue 38.16% at 710 nm. Canceration of liver induced significant increase in the scattering coefficients of liver tissue, and the maximum change in the scattering coefficients is 158.37% at 710 nm, while the minimum change in the scattering coefficients is 136.03% at 890 nm. Thermal coagulation of normal liver induced significant increase in the scattering coefficients of liver tissue, and the maximum change in the scattering coefficients is 632.92% at 890 nm, while the minimum change for the scattering coefficients is 587.40% at 710 nm. Thermal coagulation of carcinoma liver tissue induced significant increase in the scattering coefficients, and the maximum change in the scattering coefficients of carcinoma liver tissue is 384.25% at 810 nm, while the minimum change in the scattering coefficients of carcinoma liver tissue is 330.86% at 710 nm. The change in the absorption and scattering properties also varies with the change of laser wavelength.

Key words：Human liver tissue;Absorption and scattering properties;Ti:Sapphire laser;Canceration;Thermal coagulation

收稿日期: 2005-11-28 修订日期: 2006-03-06

中图分类号:

R318.5

通讯作者: 邢达 E-mail: weihj@scnu.edu.cn

引用本文:

魏华江¹,邢达^1*,何博华²,谷怀民¹,巫国勇³,陈雪梅⁴,鲁建军³ . 近红外光谱范围人肝癌变和热凝固导致组织吸收和散射特性的变化[J]. 光谱学与光谱分析, 2007, 27(05): 868-872.
WEI Hua-jiang¹,XING Da^1*,HE Bo-hua²,GU Huai-min¹,WU Guo-yong³,CHEN Xue-mei⁴,LU Jian-jun³ . Canceration and Thermal Coagulation of Human Liver Induced Changes in the Absorption and Scattering Properties of Liver-Tissue at Near Infrared in vitro. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2007, 27(05): 868-872.

链接本文:

https://www.gpxygpfx.com/CN/Y2007/V27/I05/868

[1] Kitai T, Miwa M, Liu H L, et al. Phys. Med. Biol., 1999, 44: 2049.
[2] Ritz J P, Roggan A, Germer C T, et al. Lasers Surg. Med., 2001, 28: 307.
[3] Esenaliev R O, Larin K V, Larina I V, et al. SPIE, 1999, 3726: 560.
[4] Ritz J P, Roggan A, Isbert C, et al. Lasers Surg. Med., 2001, 29: 205.
[5] Curley S A, Izzo F. Int. J. Clin. Oncol., 2002, 7: 72.
[6] Chang I. Bio. Medical Engineering, On Line, 2003, 2: 12.
[7] LI Bu-hong, XIE Shu-sen, LU Zu-kang (李步洪, 谢树森, 陆祖康). Spectroscopy and Spectral Analysis (光谱学与光谱分析)，2002, 22(6): 902.
[8] CHEN Rong, XIE Shu-sen, CHEN Yan-jiao，et al(陈荣, 谢树森, 陈艳娇, 等). J. Optoelectronics·Laser (光电子·激光), 2002, 13(1): 92.
[9] ZHU Dan, LUO Qing-ming, ZENG Shao-qun，et al(朱丹, 骆清铭, 曾绍群, 等). Acta Optica Sinica(光学学报), 2002, 22(3): 369.
[10] Wei Huajiang, Xing Da, Wu Guoyong，et al. J. Biomed. Opt., 2005, 10(4): 1.
[11] Yova D, Atlamazoglou V, Kavantzas N, et al. Lasers Med. Sci., 2000, 15: 140.
[12] Murrer LHP, Marijnissen JPA, Star WM. Phys. Med. Biol., 1995, 40: 1807.
[13] Germer CT, Albrecht D, Roggan A, et al. Br. J. Surg., 1997, 84: 317.
[14] Solonenko M, Cheung R, Busch TM, et al. Phys. Med. Biol., 2002，47: 857.
[15] Rovers JP, de Jode ML, Grahn MF. Lasers Surg. Med., 2000, 27: 235.
[16] Nilsson AMK, Berg R, Andersson-Engels S. Appl. Opt., 1995; 34: 4609.
[17] Laufer J. SPIE，2001，4250: 591.
[18] JIANG Shi-chen, ZHANG Xue-xue(江世臣, 张学学). Chinese Journal of Lasers(中国激光). 2005, 32(4): 581.
[19] WEI Hua-jiang, XING Da, WU Guo-yong, et al(魏华江, 邢达, 巫国勇, 等). Spectroscopy and Spectral Analysis(光谱学与光谱分析)，2004, 24(9): 1039.
[20] WEI Hua-jiang, XING Da, WU Guo-yong, et al(魏华江, 邢达, 巫国勇, 等). Spectroscopy and Spectral Analysis(光谱学与光谱分析)，2004, 24(11): 1296.
[21] Zhu D, Luo QM, Cen J. Lasers. Surg. Med., 2003, 33: 226.
[22] Pickering JW, Moes CJM, Sterenborg HJCM, et al. J. Opt. Soc. Am., 1992, 9: 621.
[23] van Hillegersberg R, Pickering JW, Aalders M, et al. Lasers Surg. Med., 1993, 13: 31.
[24] Prahl SA, van Gemert MJC, Welch AJ. Appl. Opt., 1993, 32: 559.
[25] Bolin FP, Preuss LE, Taylor RC, et al. Appl. Opt., 1989, 28: 2297.
[26] XU Yi-zhuang, ZHAO Ying, XU Zhi, et al(徐怡庄，赵莹，徐智，等). Spectroscopy and Spectral Analysis(光谱学与光谱分析)，2005，25(11)：1775.