Preparation and Spectroscopic of Vanadyl(Ⅱ) Vitamin D3 Amino Acid Mixed Complexes as Insulin Mimetic Drug
Enas Aljuhani1, Amnah M. A. Alsuhaibani2, A. M. El-Didamony3, N. Hassan4, Sameh Abo Taleb4, Moamen S. Refat4,5*
1. Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah, P.O.9168 Zip Code 21955, Saudi Arabia
2. Nutrition and Food Sciences Dept., Home Economic College, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
3. Department of Chemistry, Faculty of Science, Zagazig University, Egypt
4. Department of Chemistry, Faculty of Science, Port Said, Port Said University, Egypt
5. Chemistry Department, Faculty of Science, Taif University, P. O. Box 888, Al-Hawiah, Taif 21974, Saudi Arabia
Preparation and Spectroscopic of Vanadyl(Ⅱ) Vitamin D3 Amino Acid Mixed Complexes as Insulin Mimetic Drug
Enas Aljuhani1, Amnah M. A. Alsuhaibani2, A. M. El-Didamony3, N. Hassan4, Sameh Abo Taleb4, Moamen S. Refat4,5*
1. Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah, P.O.9168 Zip Code 21955, Saudi Arabia
2. Nutrition and Food Sciences Dept., Home Economic College, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
3. Department of Chemistry, Faculty of Science, Zagazig University, Egypt
4. Department of Chemistry, Faculty of Science, Port Said, Port Said University, Egypt
5. Chemistry Department, Faculty of Science, Taif University, P. O. Box 888, Al-Hawiah, Taif 21974, Saudi Arabia
摘要： A new six intraperitoneal injection insulin-mimetic vanadyl(Ⅱ) compounds [(VD-13)(VO+2)(AA-1n)] (where (n=1～6); AA1=isoleucine, AA2=threonine, AA3=proline, AA4=phenylalanine, AA5=lysine and AA6=glutamine) were synthesized by the chemical reactions between vitamin D3 (VD3), VOSO4 and amino acids (AAn) with equal molar ratio 1∶1∶1 in neutralized media. The structures of these complexes were elucidated by spectroscopic methods like, infrared and solid reflectance spectroscopes. Magnetic moments and electronic spectra reveal square pyramid geometrical structure of the complexes. The infrared spectra assignments of these complexes revealed that the chelation towards vanadyl(Ⅳ) ions existed via deprotonation of the hydroxyl group of VD3 drug ligand and so amino acids act as bidentate ligand via N-amino and O-carboxylate groups. The anti-diabetic efficiency of these complexes were evaluated against streptozotocin induced diabetic male albino rats.
Abstract：A new six intraperitoneal injection insulin-mimetic vanadyl(Ⅱ) compounds [(VD-13)(VO+2)(AA-1n)] (where (n=1～6); AA1=isoleucine, AA2=threonine, AA3=proline, AA4=phenylalanine, AA5=lysine and AA6=glutamine) were synthesized by the chemical reactions between vitamin D3 (VD3), VOSO4 and amino acids (AAn) with equal molar ratio 1∶1∶1 in neutralized media. The structures of these complexes were elucidated by spectroscopic methods like, infrared and solid reflectance spectroscopes. Magnetic moments and electronic spectra reveal square pyramid geometrical structure of the complexes. The infrared spectra assignments of these complexes revealed that the chelation towards vanadyl(Ⅳ) ions existed via deprotonation of the hydroxyl group of VD3 drug ligand and so amino acids act as bidentate ligand via N-amino and O-carboxylate groups. The anti-diabetic efficiency of these complexes were evaluated against streptozotocin induced diabetic male albino rats.
Enas Aljuhani, Amnah M. A. Alsuhaibani, A. M. El-Didamony, N. Hassan, Sameh Abo Taleb, Moamen S. Refat. Preparation and Spectroscopic of Vanadyl(Ⅱ) Vitamin D3 Amino Acid Mixed Complexes as Insulin Mimetic Drug[J]. 光谱学与光谱分析, 2019, 39(07): 2316-2324.
Enas Aljuhani, Amnah M. A. Alsuhaibani, A. M. El-Didamony, N. Hassan, Sameh Abo Taleb, Moamen S. Refat. Preparation and Spectroscopic of Vanadyl(Ⅱ) Vitamin D3 Amino Acid Mixed Complexes as Insulin Mimetic Drug. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2019, 39(07): 2316-2324.
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