Abstract：Water-soluble inclusion compounds of β-cyclodextrin with lycopene were prepared by two methods: (1) complexation in solution and (2) complexation by kneading. It was found that UV-Vis spectra of the inclusion complexes in water are different from those of lycopene in water-miscible organic solvents (tetrahydrofuran) and β-cyclodextrin in water, which confirms the formation of the inclusion complexes. Specific interactions of lycopene and β-cyclodextrin cause great changes in absorbance maximum (λmax) of lycopene. It is considered that the inclusion complexes in water are formed as supermolecular aggregates with nanometer size, after card-pack type lycopene is included by β-cyclodextrin in molecular level.
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