夜晚蓝光和白光暴露对肝脏生物钟节律和肝脏炎症反应影响的差异

梁昕悦^1,², 曾晶², 艾常鹏³, 罗杰承³, 范晓静⁴, 吴胜男^3,^*, 顾瑛^1,^2,^3,^*

Differences in the Effects of Night Blue Light and White Light Exposure on Liver Circadian Rhythm and Inflammatory Response

LIANG Xin-yue^1,², ZENG Jing², AI Chang-peng³, LUO Jie-cheng³, FAN Xiao-jing⁴, WU Sheng-nan^3,^*, GU Ying^1,^2,^3,^*

肝脏组织免疫荧光染色 (a): 代表性免疫荧光图; 绿色标记白介素17A蛋白, 红色标记GM-CSF蛋白, 蓝色标记细胞核; (b): 荧光信号定量分析( n =6; ** p <0.01, *** p <0.001 vs. 对照组) 注: Ctl: 对照组; LAN-WL-1h: 夜晚白光1 h组; LAN-WL-3h, 夜晚白光3 h组; LAN-BL-1h: 夜晚蓝光1 h组; LAN-BL-3h: 夜晚蓝光3 h组; IL-17A: 白介素17A; GM-CSF: 粒细胞-巨噬细胞集落刺激因子; DAPI: 4’,6-二脒基-2-苯基吲哚