表面增强拉曼散射技术在核酸检测中的研究进展及应用

田晖艳¹, 刘羽¹, 黄姣祺¹, 谢凤欣¹, 黄国荣¹, 廖璞¹, 府伟灵¹, 张阳^2,^*

Research Progress and Application of Surface-Enhanced Raman Scattering Technique in Nucleic Acid Detection

TIAN Hui-yan¹, LIU Yu¹, HUANG Jiao-qi¹, XIE Feng-xin¹, HUANG Guo-rong¹, LIAO Pu¹, FU Wei-ling¹, ZHANG Yang^2,^*

(A)核酸修饰纳米Au为基底及拉曼活性分子包被的Au核Au壳SERS标签(a)及Ag微球SERS基底(b)结构示意图; (B)“夹心法”SERS探针高通量检测miRNAs示例图; (C)单一miRNA的SERS光谱检测结果图(a)及多个miRNA的SERS光谱检测结果图(b)^{[ 19 ]}