光谱学与光谱分析 |
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Study on Specificity of Noninvasive Glucose Measurements Based on Two-Dimensional Correlation Mid-Infrared Spectroscopy |
ZHANG Wen1, CAO Yu-zhen1*, LIU Rong2, XU Ke-xin2 |
1. College of Precision Instrument & Opto-electronics Engineering,Tianjin University,Tianjin 300072,China 2. State Key Laboratory of Precision Measuring Technology and Instruments,Tianjin University,Tianjin 300072,China |
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Abstract Glucose specificity is the premise of spectroscopic measurements of blood glucose concentration, and it is also paramount for feasibility study of a spectral measurement method. Two-dimensional correlation spectroscopy technology is widely used in many fields such as inter-/intra-molecular reaction, material phase transition and information extraction because of its high resolution and effective Noda’s rule. In the present paper, the glucose specificity for noninvasive glucose measurements by mid-infrared spectra based on the 2D correlation spectroscopy was investigated. First, the feasibility of this method was validated by a series of in vitro experiments of glucose. Then the in vivo experiments of four volunteers were conducted and the characteristic information of glucose by mid-infrared spectra collected from human fingers was confirmed by 2D correlation spectroscopy analysis.
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Received: 2011-09-05
Accepted: 2011-12-20
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Corresponding Authors:
CAO Yu-zhen
E-mail: yzcao@tju.edu.cn
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