| 光谱学与光谱分析 |
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| The Action Mechanism of 8-Azaadenine and Its Metal Complexes with DNA |
| XI Xiao-li, YANG Man-man,YANG Pin* |
| Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China |
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Abstract The mechanism of the interactions of 8-azaadenine and its Co2+ and Cu2+ complexes with DNA was studied by UV and fluorescence spectra using ethidium bromide(EB) as the probe molecule. When pH 9.86, the action of 8-azaadenine-Co2+ with DNA was electrostatic effect and certain kind of intercalation action, when pH 7.4, the action of 8-azaadenine-Cu2+ with DNA was intercalation action and certain kind of electrostatic effect, when pH 2.85, the action was intercalation action and certain kind of electrostatic effect. But when pH 7.4, 8-azaadenine hardly influenced the intercalation action of EB and DNA, and the action of 8-azaadenine and DNA was electrostatic action.
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Received: 2005-08-16
Accepted: 2005-11-28
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Corresponding Authors:
YANG Pin
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| Cite this article: |
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XI Xiao-li,YANG Man-man,YANG Pin. The Action Mechanism of 8-Azaadenine and Its Metal Complexes with DNA[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2006, 26(12): 2272-2275.
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| URL: |
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https://www.gpxygpfx.com/EN/Y2006/V26/I12/2272 |
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