| 光谱学与光谱分析 |
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| Synthesis and DNA Binding Spectroscopic Studies of Cu(Ⅱ)-HAsp-Im Complexes |
| ZHANG Fang, ZHANG Qian-qian*,LU Xiao-lan, JIANG Tao, WANG Xiu-lin |
| College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266003, China |
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Abstract Two novel complexes of [Cu(HAsp)ImH2O]SO4·4H2O and [Cu(Asp)Im(OH)]·4H2O (HAsp=Aspartic acid molecule, Asp=Aspartic acid ion, Im=Imidazole) were synthesized and characterized by elemental analysis, IR spectroscopy and TG-DTA. The interactions of the complexes with sperm DNA were studied by electronic absorption and fluorescence spectra. Results showed that the reactions of the two complexes with DNA are obviously different: for [Cu(HAsp)ImH2O]SO4·4H2O, it is intercalation companied by electrostatic effect, while [Cu(Asp)Im(OH)]·4H2O mainly cooperates with the nitrogen atom of the DNA base pair, which induces the breakage of DNA double helix. The reasons for these differences in their DNA binding modes were also discussed.
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Received: 2005-11-16
Accepted: 2006-02-26
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Corresponding Authors:
ZHANG Qian-qian
E-mail: qqzhang@mail.ouc.edu.cn
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| Cite this article: |
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ZHANG Fang,ZHANG Qian-qian,LU Xiao-lan, et al. Synthesis and DNA Binding Spectroscopic Studies of Cu(Ⅱ)-HAsp-Im Complexes[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2007, 27(02): 302-305.
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| URL: |
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https://www.gpxygpfx.com/EN/Y2007/V27/I02/302 |
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