Application of Raman Spectroscopy to the Research on Hemoglobin Structure and Function
LU Ming-zi1, GUO Yan-jun2, ZHAO Lian1*, ZHOU Hong1*
1. Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing 100850, China 2. National Center for Nanoscience and Technology, Beijing 100190, China
Abstract：Hemoglobin plays many significant biological roles in organism. However, our knowledge about its structure and function is not enough to meet the demand of clinical diagnosis. Raman spectroscopy has been shown to be an attractive optical technique which can provide direct access to the structure and function of hemoglobin. It is a proven tool for elucidating structural information of hemes and other vicinal groups. Furthermore, it can provide a useful monitor for hemoglobin dynamics. Besides, Raman spectroscopy has notable advantages in the fields of abnormal hemoglobin diagnosis, hemoglobin oxygen saturation determination and blood methemoglobin analysis. The present paper reviews the research on hemoglobin structure and function using Raman spectroscopy and the application in hemoglobinopathy diagnosis. In addition, we discuss the factors affecting the measurement in Raman spectroscopy of hemoglobin. The aim of the review is to promote the application of Raman spectroscopy to the research of hemoglobin structure and function.
卢明子1，郭延军2，赵 莲1*，周 虹1* . 拉曼光谱在血红蛋白结构及功能研究中的应用进展 [J]. 光谱学与光谱分析, 2014, 34(02): 439-444.
LU Ming-zi1, GUO Yan-jun2, ZHAO Lian1*, ZHOU Hong1* . Application of Raman Spectroscopy to the Research on Hemoglobin Structure and Function. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2014, 34(02): 439-444.
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