Preparation of and Study on Magnetic Resonance Imaging Performance of Metal Porphyrin Modified by Low Molecular Weight Chitosan
YU Dong-jun1, LI Min-zhi1, HUANG Xian-zhu1, ZHU Wei-hua1, HUANG Yan1, ZHANG Qi1, 2*, LIU Qing1
1. Department of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China 2. Hainan Provincial Key Laboratory of Fine Chemistry (Hainan University), Haikou 570228, China
Abstract：The functional complex Mn-TCPP-CS20 as a potential magnetic resonance imaging (MRI) contrast agent was synthesized through tetra(4-carboxyphenyl) Mn(Ⅱ)-porphyrin (Mn-TCPP) modified by CS20, which was low degree of polymerization and narrow distribution. The results showed that Mn-TCPP-CS20 had good water-solubility and structural stability. The chemical structures of the products were characterized with Fourier transform infrared spectra (FTIR), UV-Vis spectra, mass spectrum (MS) and inductively coupled plasma atomic emission spectrometry (ICP-AES). The results showed that Mn-TCPP was successfully linked to CS20 by an amide function. The relaxation properties in vitro of the functional complex Mn-TCPP-CS20 as the potential MRI contrast agent were preliminarily studied. It was found that the longitudinal relaxivity (r1) of the synthesized Mn-TCPP-CS20 (6.11 mmol-1·L·s-1) was higher than that of the commercial contrast agent Gd-DTPA (r1=3.59 mmol-1·L·s-1). Besides, the imaging effect of Mn-TCPP-CS20 was superior to that of Gd-DTPA in the same condition. These studies suggested that Mn-TCPP-CS20 has the advantage of becoming a potential tissue-targeting contrast agent.
俞东军1，李敏智1，黄显著1，朱卫华1，黄 燕1，张 岐1, 2*，刘 清1 . 壳聚糖修饰金属卟啉的制备及磁共振成像性能 [J]. 光谱学与光谱分析, 2013, 33(10): 2736-2739.
YU Dong-jun1, LI Min-zhi1, HUANG Xian-zhu1, ZHU Wei-hua1, HUANG Yan1, ZHANG Qi1, 2*, LIU Qing1 . Preparation of and Study on Magnetic Resonance Imaging Performance of Metal Porphyrin Modified by Low Molecular Weight Chitosan . SPECTROSCOPY AND SPECTRAL ANALYSIS, 2013, 33(10): 2736-2739.
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