1. School of Public Health, Peking University, Beijing 100083, China 2. Laboratory of Biometallomics, Center of Medical & Health Analysis, Peking University, Beijing 100083, China 3. Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Union Medical College, Tianjin 300192, China
Abstract：Changes in content and distribution of elements in human tissues may reflect changes in environmental backgrounds, and are closely related to human health. To investigate the change in element background in normal lung tissue in different stage, we used ICP-MS, ICP-AES and GFAAS to determine 51 element contents in normal human lung samples of 1982-83 year (n=7) and compare with those of 2004-05 year (n=16). Samples were from healthy male adults who died suddenly, and were treated with microwave digestion and wet digestion method. The results show that the contents of 23 elements (Na, Mg, P, K, As, Mo, Ag, Ba, Bi, Y, La, Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu) are significantly higher, and 6 elements (Zn, Ga, Ge, Se, Au and Zr) are significantly lower in the 2004-05 samples than those in the 1982-83 samples. This difference would be related to the changes in environmental backgrounds and people’s living habit during twenty years. The distinctive decrease in contents of the 2004-05 samples for most measured rare earth elements (REEs) may be due to more rational usage of REEs in present, while were the soil and corps were largely abused in 1980s in China. The significant increase in contents of some useful micro-elements (Zn and Se ) in the present samples maybe because of the increased intake of these elements as people own more health consciousness. Besides, the increased contents of heavy metal Pb, Cd, Cr and Ni in the present samples may be related to the deterioration of air quality as industrialization course. More than half of measured elements have been significantly changed over twenty years, indicating that some normal value ranges of element contents should be adjusted according to the difference.
曾静1,2,欧阳荔1,2,王小燕1,2,刘雅琼2,解清2,诸洪达3,武权3,樊体强3,王京宇1,2*. 20年前后正常人肺组织51种元素含量比较[J]. 光谱学与光谱分析, 2008, 28(05): 1153-1156.
ZENG Jing1,2,OUYANG Li1,2,WANG Xiao-yan1,2,LIU Ya-qiong2,XIE Qing2,CHU Hong-da3,WU Quan3,FAN Ti-qiang3,WANG Jing-yu1,2*. Comparison of 51 Element Contents in Normal Human Lung Tissue over Twenty Years. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2008, 28(05): 1153-1156.
[1] YAN Fang, YAN Wei-qun, ZHANG Pu-qing, et al(闫 芳，闫伟群，张普庆，等). Chinese Journal of Clinic Nutrition(中国临床营养杂志), 2002, 10(3): 214. [2] ZHANG Jin-liang, CHEN Qing, WANG Nai-fen, et al(张金良，陈 清，王耐芬，等). Journal of Hygiene Research(卫生研究), 2003, 23(5): 423. [3] ZHU Xiao-ling , ZHANG Shang-fu, JIANG Yong, et al(朱晓玲，张尚福，姜 勇，等). China Journal of Lung Cancer(中国肺癌杂志), 2004, 7(3): 222. [4] WANG Jing-yu, CHU Hong-da, OUYANG Li, et al(王京宇，诸洪达，欧阳荔，等). Spectroscopy and Spectral Analysis(光谱学与光谱分析), 2004, 24(9): 1117. [5] LIU Su-jing, ZHOU Qing(刘苏静，周 青). Chinese Journal of Eco-Agriculture(中国生态农业学报)，2007，15(3)：181. [6] CHEN Zu-yi(陈祖义). Rural Eco-Environment(农村生态环境)，1999，15(3)：44. [7] CHEN Zu-yi, ZHU Xu-dong(陈祖义，朱旭东). Journal of Ecology and Rural Environment(生态与农村环境学报)，2006，22(3)：93. [8] ZHANG Ju, MIAO Hong, OUYANG Zhi-yun, et al(张 菊，苗 鸿，欧阳志云，等). Acta Scientiae Circum Stantiae(环境科学报)，2006，26(11)：1886. [9] HU Xing-ming, WANG Li-ping, BI Jian-hong(胡星明，王丽平，毕建洪). Journal of Anhui Agri. Sci.(安徽农业科学)，2008，36(3)：302.
