Noninvasive Measurement of Serum Total Protein Content by Near-Infrared Reflection Spectra with Tongue Inspection
LIN Ling1, LI Zhe1, LI Xiao-xia2, LI Yong-cheng1, LI Gang1, ZHANG Bao-ju3, SONG Wei3*
1. State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin 300072, China 2. Province-Ministry Joint Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability, School of Electrical Engineering, Hebei University of Technology, Tianjin 300130, China 3. College of Physics & Electronic Information, Tianjin Normal University, Tianjin 300387, China
Abstract：The technology of tongue near-infrared reflectance spectra was used for human serum total protein (TP) content of noninvasive testing for the first time. Reflectance spectrum on the tongue tips of 58 volunteers was collected, and the biochemical values of serum total protein were recorded at the same time. The samples were separated into two parts: training set and prediction set. Two prediction models were established using PCA combined with BP neural network and PLS. Using PCA-BP model to predict the prediction set, the average relative error is 7.35%, RMSEP was 6.377 1 g·L-1, and the correlation coefficient was 0.902 1. Using PLS model to predict the prediction set, the average relative error is 4.77%, RMSEP was 0.130 4 g·L-1, and the correlation coefficient was 0.971 8. It was approved that reflectance spectra of tongue can be used to predict TP accurately and noninvasively.
Key words：NIR normalized reflection spectroscopy;Tongue inspection;Total protein (TP);BP neural networks;Partial least squares
林 凌1，李 哲1，李晓霞2，李永成1，李 刚1，张宝菊3，宋 维3* . 基于舌诊NIR反射光谱血清总蛋白含量的无创测量[J]. 光谱学与光谱分析, 2012, 32(08): 2110-2116.
LIN Ling1, LI Zhe1, LI Xiao-xia2, LI Yong-cheng1, LI Gang1, ZHANG Bao-ju3, SONG Wei3* . Noninvasive Measurement of Serum Total Protein Content by Near-Infrared Reflection Spectra with Tongue Inspection. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2012, 32(08): 2110-2116.
