Far-IR and THz Absorption Spectra Studies of Metronidazole, Tinidazole and Ornidazole
ZHANG Zhen-wei, ZUO Jian, ZHANG Cun-lin
Department of Physics, Capital Normal University, Beijing Key Lab for Terahertz Spectroscopy and Imaging, Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing 100048, China
Abstract：Metronidazole, tinidazole and ornidazole are 5-nitro-imidazole medicines used particularly for anaerobic bacteria and protozoa infections. The present paper reports that terahertz time-domain spectroscopy (THz-TDS) and Fourier transform infrared spectroscopy (Far-FTIR) were used to measure the fingerprint spectra of metronidazole, tinidazole and ornidazole in the frequency range of 0.9~19.5 THz under the room temperature. In addition, THz-TDS was also used to measure the absorption spectra of pure tinidazole and tinidazole tablets from different manufactures between 0.2 and 2.2 THz. In parallel with the experimental study, the cross correlation analysis was applied to compare the array of correlation coefficients between pure tinidazole and different tinidazole tablets. Results show that the method is rapid, simple and accurate to identify their effective chemical compositions and stability when the FTIR and THz spectra data combine with the array of correlation coefficient. Our research provides a visual approach to the standardization and modernization of the quality control in the production and sale of such drugs.
[1] Jokipii L, Jokipii A M M. J. Antimicrob. Chemother，1977, 3: 571. [2] State Pharmacopoeia Commission of China(国家药典委员会). Pharmacopoeia of People’s Republic of China(Ⅱ)(中华人民共和国药典·二部). Beijing: Chemical Industry Press(北京：化学工业出版社), 2000. 157. [3] State Pharmacopoeia Commission of China(国家药典委员会). Atlas of Infrared spectra of Drugs (Ⅰ)(药品红外光谱集·第1卷). Beijing: Chemical Industry Press(北京：化学工业出版社), 1995. 112, 665. State Pharmacopoeia Commission of China(国家药典委员会). Atlas of Infrared spectra of Drugs (Ⅲ)(药品红外光谱集·第3卷). Beijing: Chemical Industry Press(北京：化学工业出版社), 2005. 1052. [4] WANG Wei-ning, LI Hong-qi, ZHANG Yan, et al(王卫宁, 李洪起, 张 岩，等). Acta Phys.-Chim. Sin.(物理化学学报)，2009，25(10)：2074. [5] Melinger J S，Harsha S S，Laman N，et al. J. Opt. Soc. Am. B.，2009, 26(9): A79. [6] Shi Y L，Wang L. Journal of Physics D：Applied Physics, 2005, 38：3741. [7] Laman N, Harsha S S，Grischkowsky D. Melinger, J. S. Biophysical Journal, 2008, 94(2): 1010. [8] Kawase K, Ogawa Y，Watanabe Y. Opt. Express, 2003, 11(20): 2902. [9] Zhou Q L，Zhang C L，Mu K J，et al. Appl. Phys. Lett., 2008, 92: 101106. [10] Laman N, Harsha S S，Grischkowsky D. Appl. Spectrosc., 2008, 62(3): 319. [11] MA Jin-long, XU Kai-jun, LI Zhe，et al(马金龙, 徐开俊, 李 哲，等). Acta Phys. Sin.(物理学报), 2009, 58(9)：6101. [12] XU Lu，SHAO Xue-guang(许 禄, 邵学广). Methods of Chemometrics(化学计量学方法). Beijing: Science Press(北京：科学出版社), 2006. 75.
