流动注射化学发光测定盐酸丙卡特罗

doi:10.3964/j.issn.1000-0593.2008.02.009

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摘要：发现盐酸丙卡特罗(Procaterol hydrochloride)在硫酸介质中能与铈(Ⅳ)和罗丹明B产生微弱的化学发光，而在该体系中加入盐酸和表面活性剂CTMAB，能显著增强化学发光的强度。探索了该化学发光体系最佳的反应条件，初步提出了该体系的反应机理，据此建立了流动注射化学发光测定盐酸丙卡特罗的新方法，线性响应范围为2×10^-8g·mL^-1～1×10-6g·mL^-1,检出限为6×10^-9g·mL^-1；对2.0×10^-7g·mL^-1盐酸丙卡特罗连续11次平行测定的相对标准偏差为1.6％，该方法用于测定盐酸丙卡特罗片剂并与标准方法(中国药典法)比较，结果令人满意。

关键词：化学发光;流动注射;盐酸丙卡特罗;铈(Ⅳ);罗丹明B

Abstract：A new flow injection chemiluminescences method for the determination of procaterol hydrochloride has been developed. It is based on the chemiluminescence reaction of procaterol hydrochloride with Ce(Ⅳ)-rhodamine B in sulphuric-chlorhydric acid medium and the experimental fact of the enhancement of chemiluminescence by surfactant CTMAB. The concentration of the analyte shows a good linear relationship with the produced luminescence intensity in the range of 2.0×10^-8g·mL^-1 to 1.0×10^-6g·mL^-1. The detection limit of the proposed method is 6×10^-9g·mL^-1 and the RSD is 1.6％(n=11) at 2×10^-7g·mL^-1. This result is satisfactory compared with the method mentioned in the pharmacopoeia of People’s Republic of China.

Key words：Chemiluminescence;Flow injection;Procaterol hydrochloride;Ce(Ⅳ);Rhodamine B

收稿日期: 2006-08-10 修订日期: 2006-12-20

中图分类号:

O657.3

通讯作者: 饶志明 E-mail: raozhm@163.com

引用本文:

饶志明¹,邹苹¹,陈梅¹,修福荣¹,陈育琳²,洪可俊² . 流动注射化学发光测定盐酸丙卡特罗[J]. 光谱学与光谱分析, 2008, 28(02): 269-272.
RAO Zhi-ming¹,ZOU Ping¹,CHEN Mei¹,XIU Fu-rong¹,CHEN Yu-lin²,HONG Ke-jun². Flow-Injection Chemiluminescence Determination of Procaterol Hydrochloride . SPECTROSCOPY AND SPECTRAL ANALYSIS, 2008, 28(02): 269-272.

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