The Study on the Preparation and Spectroscopic Properties of Hydroxypropyl-β-Cyclodextrin/Glipizide Inclusion Complex
ZHANG Yi-min,LI Xiao,SUN Cong-shan,CHEN Chun-feng
Key Laboratory for Green Chemical Technology,Ministry of Education,School of Chemical Engineering and Technology, Tianjin University,Tianjin 300072,China
Abstract：The interaction of glipizide and hydroxypropyl-β-cyclodextrin was investigated in the present paper. The stability constant and molar ratio of glipizide and hydroxypropyl-β-cyclodextrin was calculated from the phase soluility diagram. The solid state inclusion complex of hydroxypropyl-β-cyclodextrin/glipizide prepared by neutralization method was characterized by Fourier transform infrared spectroscopy (FTIR),differential scanning calorimetry (DSC) and powder X-ray diffraction(XRD). It was found that the phase solubility diagram of the HP-β-CD solution showed a typical AL-type,suggesting the formation of a soluble complex of 1∶1 molar ratio,and the stability constant was 359 L·mol-1 at 25 ℃. The spectra of IR, thermograph of DSC and XRD pattern of the inclusion complex were remarkably different from the glipizide and hydroxypropyl-β-cyclodextrin/glipizide physical mixture,and indicated that hydroxypropyl-β-cyclodextrin/glipizide inclusion complex displayed amorphous characteristic. The experiment of solubility of inclusion complex indicated that the solubility of inclusion complex increased 25-fold.
张毅民,李潇,孙聪善,陈春凤. 羟丙基-β-环糊精/格列吡嗪包结物的制备及其光谱研究[J]. 光谱学与光谱分析, 2008, 28(03): 711-714.
ZHANG Yi-min,LI Xiao,SUN Cong-shan,CHEN Chun-feng. The Study on the Preparation and Spectroscopic Properties of Hydroxypropyl-β-Cyclodextrin/Glipizide Inclusion Complex. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2008, 28(03): 711-714.
