Applications of Real-Time Monitoring Techniques in Chemical Synthetic Ingredients
SHI Kai-yun1,XIA Zhi-ning1, 2*,GAN Ting-ting1,JIANG Xue-mei1,XIA Chen2
1. College of Bioengineering, Chongqing University, Chongqing 400030, China 2. College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, China
Abstract:Real-time monitoring technique for process parameters and/or insight variables of chemical synthetic ingredients is a novel chemical process analysis method, which can real time monitor the chemical synthetic ingredients, reveal the mechanism of chemical reaction occurring, reaction courses and kinetic characteristics, and monitor, control and adjust chemical reaction to determine the endpoint of reaction and enhance selectivity of reaction, quality and yields of product. Many real-time monitoring techniques were achieved to satisfy the demands in several chemical synthetic reactions. The structure and principles of current real-time monitoring techniques was stated, and a review was summarized on its applications in chemical synthetic ingredients. The research, development and applications of real-time monitoring techniques such as spectrometry (i.e. ultraviolet-visible spectrophotometry, infrared spectrometry, Raman spectroscopy, nuclear magnetic resonance spectroscopy, mass spectrometry and fluorescence spectroscopy), chromatography (i.e. thin layer chromatography, gas chromatography, high performance liquid chromatography and capillary electrophoresis) and their coupled techniques (i.e. GC-MS, GC-IR and LC-MS) for chemical synthetic ingredients were evaluated. The coupled techniques were utilized to take the advantages of their high performance separation and quantitative power of chromatography, and sensitive and qualitative identification capacity of spectrometric techniques could realize the real-time monitoring for special chemical synthetic ingredients in complex systems. The future developmental trends and application prospects of real-time monitoring techniques are also discussed. With the research & development of microprocessor and embedded system, the real-time monitoring instrument for chemical synthetic ingredients will have a trend to miniaturization, intelligence, digitization, functionalization and multichannel with widely versatile and strongly compatible features.
Key words:Chemical synthesis;Real-time monitoring;Infrared spectroscopy;Raman spectroscopy;Mass spectroscopy;Nuclear magnetic resonance spectroscopy
[1] Castellnou D, Fontes M, Jimeno C, et al. Tetrahedron, 2005, 61(51): 12111. [2] Daniele F. Mass Spectrometry Reviews, 2005, 24(1): 30. [3] Pedge N I, Walmsley A D. Applied Spectroscopy, 2007, 61(9): 940. [4] Heigl N, Petter C H, Rainer M, et al. Journal of Near Infrared Spectroscopy, 2007, 15(5): 269. [5] Strauss M J, Prinsloo N M. Applied Catalysis A: General, 2007, 320(1): 16. [6] Prinsloo N M, Engelbrecht J P, Mashapa T N, et al. Applied Catalysis A: General, 2008, 344(1-2): 20. [7] Pintar A, Malacea R, Pinel C, et al. Applied Catalysis A: General, 2004, 264(1): 1. [8] Sahre K, Schulze U, Hoffmann T, et al. Journal of Applied Polymer Science, 2006, 101(3): 1374. [9] Schaden S, Dominguez-Vidal A, Lendl B. Applied Spectroscopy, 2006, 60 (5): 568. [10] Lin Z H, Zhou L L, Mahajan A, et al. Journal of Pharmaceutical and Biomedical Analysis, 2006, 41(1): 99. [11] Namli H, Turhan O. Spectrochimica Acta Part A, 2006, 64(1): 93. [12] France S, Wack H, Taggi A E, et al. Journal of the American Chemical Society, 2004, 126(13): 4245. [13] Pintar A, Malacea R, Pinel C, et al. Vibrational Spectroscopy, 2007, 45(1): 18. [14] LIU Dong-feng, DU Wei-min, ZHOU He-tian, et al(刘东风, 杜为民, 周赫田, 等). Spectroscopy and Spectral Analysis(光谱学与光谱分析), 2001, 21(3): 301. [15] Mcmanus M E, Collins S M J, Collins J M J. U. S. Patent, 7141769 B2, 2006. [16] Leadbeater N E, Smith R J. Organic Letter, 2006, 8(20): 4589. [17] Leadbeater N E, Schmink J R. Nature Protocols, 2008, 3(1): 1. [18] Takahashi Y, Sakai A, Kitamori T. J. Patent, 日本特开2006-90955 A, 2006. [19] Gal M, Mishkovsky M, Frydman L. Journal of the American Chemical Society, 2006, 128(3): 951. [20] Holzgrabe U, et al. NMR Spectroscopy in Pharmaceutical Analysis, Netherlands: Elsevier, 2008. 471. [21] Wensink H, Benito-Lopez F, Hermes D C, et al. Lab on a Chip, 2005, 5: 280. [22] Takahashi Y, Nakakoshi M, Sakurai S, et al. Analytical Sciences, 2007, 23(4): 395. [23] Roy A D, Jayalakshmi K, Dasgupta S, et al. Magnetic Resonance in Chemistry, 2008, 46(12): 1119. [24] Clinton R, Creaser C S, Bryant D. Analytica Chimica Acta, 2005, 539(1-2): 133. [25] Brivio M, Tas N R, Goedbloed M H, et al. Lab on a Chip, 2005, 5: 378. [26] Zhu L, Gamez G, Chen H W, et al. Rapid Communications in Mass Spectrometry, 2008, 22(19): 2993. [27] Marchand G, Dubois P, Delattre C, et al. Analytical Chemistry, 2008, 80 (15): 6051. [28] Leadbeater N E, Shoemaker K M. Organometallics, 2008, 27(6): 1254. [29] Al-Gailani B R M, McCreedy T. Chemical Communications, 2003, (1): 120. [30] Loncar-Tomaskovic L, Pustet N, Mrvos-Sermek D, et al. Chirality, 2001, 13(2): 81. [31] Dantan N, Frenzel W, Küppers S. Chromatographia, 2001, 54(3-4): 187. [32] GUO Ming-xing, GUO Hong-chen, WANG Xiang-sheng, et al(郭明星, 郭洪臣, 王祥生, 等). Chemical Journal of Chinese Universities(高等学校化学学报), 2005, 26(3): 527. [33] Liu D Q, Wu L M, Sun M J, et al. Journal of Pharmaceutical and Biomedical Analysis, 2007, 44(2): 320. [34] Guo C N, Shah R D, Dukor R K, et al. Analytical Chemistry, 2004, 76(23): 6956. [35] Guo C N, Shah R D, Dukor R K, et al. Applied Spectroscopy, 2005, 59(9): 1114.