Temperature Effect on the Noninvasive Measurement of Human Blood Glucose by NIR
CUI Hou-xin, XU Ke-xin, CHEN Min-sen, AN Lin
College of Precision Instrument and Opto-Electronics Engineering, State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, Tianjin 300072, China
Abstract：During the noninvasive measurements of body blood glucose, the result will be effected by many factors, such as the measuring conditions including temperature, contact pressure and so on, and in addition the change of body’s state also will induce some error. However, among so many factors the temperature is very important and should be discussed. To find the quantitative value of the result bias caused by temperature in the wavelength range from 1 100 to 1 700 nm, the aqueous glucose with the concentration ranging from 10 mg·dL-1 to 200 mg·dL-1 and 10 mg·dL-1 interval was detected at temperature of 15, 20, 25, 30, 35 and 40℃. Then six different models at different temperature were founded and predicted one another. The maximum RMSEP result of models is 11.227 9 mg·dL-1 and the minimum is 3.298 8 mg·dL-1. The correlation is about 0.98. The authors have also found that 1 ℃ change of temperature will induce Δc＝2.662(mg·dL-1·℃-1)change of the prediction result, so these show that the detect error will be minimal when the temperature of measuring is the same as that of modeling. Moreover, the authors put forward two approaches to decreasing or compensating the error induced by the temperature.
崔厚欣，徐可欣，陈民森，安林. 人体血糖浓度近红外光谱无创检测过程中温度对结果的影响[J]. 光谱学与光谱分析, 2006, 26(05): 838-841.
CUI Hou-xin, XU Ke-xin, CHEN Min-sen, AN Lin. Temperature Effect on the Noninvasive Measurement of Human Blood Glucose by NIR. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2006, 26(05): 838-841.
[1] HUANG Lan, DING Hai-shu, WANG Guang-zhi(黄 岚，丁海曙，王广志). Spectroscopy and Spectral Analysis(光谱学与光谱分析)，2002，22(3)：387. [2] Khall Omar S. Clinical Chemistry, 1999, 45(2): 165. [3] Tarumi Masatoshi, Shimada Mitsunori, Murakami Tomoya, et al. Phys. Med. Biol., 2003, 48: 2373. [4] Fornes V, Chaussidon J. J. Chem. Phys., 1978, 68: 4667. [5] Simpson J L R, Kohl M, et al. Phys. Med. Biol., 1998, 43: 2479. [6] Jacques S L. Journal of Optical Society of America, 1996, 2: 364. [7] Saidi I S, Jacques S L, Tittel F K. Appl. Opt., 1995, 34: 7410. [8] Khall Omar S, Yeh Shu-jen, Lowery Michael G, et al. Journal of Biomedical Optics, 2003, 8(2): 191. [9] SHEN Tao, PENG Qing, WENG Shi-fu, et al(沈 韬，彭 卿，翁诗甫，等). Spectroscopy and Spectral Analysis(光谱学与光谱分析)，1996，16(3)：39.
