Structure Analysis of Benzoic Medicines by Near Infrared and Two Dimensional Correlation Spectroscopy
LIU Hao1,XIANG Bing-ren2*,QU Ling-bo3,XU Jian-ping2
1. Department of Pharmacy, Guangdong Chemical Engineering Pharmaceutics College, Guangzhou 510520, China 2. Center for Analysis and Measurement, China Pharmaceutical University, Nanjing 210009, China 3. Anyang Teachers College, Anyang 455002, China
Abstract：The structure analysis of benzoic medicines by Fourier transform near infrared spectroscopy and generalized two dimensional correlation spectroscopy was performed. Three kinds of medicines showed unconspicuous changes in one-dimensional near infrared spectra, while the two dimensional correlation spectra showed high resolution，and were more explicable. By the comparison and analysis of raw near infrared spectra and 2D-correlation spectra, the near infrared absorption peaks of benzoic acid medicines were assigned，and their structure characteristics were analyzed, the results affirmed the six-membered ring intramolecular hydrogen bond especially. The study is helpful to the in-depth understanding of benzoic medicines, and provides information for the future study and utilization of benzoic medicines.
刘浩1,相秉仁2*,屈凌波3,徐建平2. 芳酸类药物的近红外及二维相关(2DCorr)光谱分析[J]. 光谱学与光谱分析, 2007, 27(02): 265-269.
LIU Hao1,XIANG Bing-ren2*,QU Ling-bo3,XU Jian-ping2 . Structure Analysis of Benzoic Medicines by Near Infrared and Two Dimensional Correlation Spectroscopy. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2007, 27(02): 265-269.
