Human Gastric Tubular Adenocarcinoma Tissue Detection Based on Terahertz Time Domain Spectroscopy and Tissue Microarray Technology
ZHANG Yi1,2, HUANG Ping-jie1,2*, GE Wei-ting1,2, CAO Yu-qi1,2, HOU Di-bo1,2, ZHANG Guang-xin1,2
1. State Key Laboratory of Industrial Control Technology, College of Control Science and Engineering, Zhejiang University, Hangzhou 310027, China
2. Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, the Second Affiliated Hospital, Zhejiang University, College of Medicine, Hangzhou 310009, China
Abstract：Terahertz wave technique is very prospective in the biomedical application field，where there exists a practical problem that it is hard to register a terahertz time-domain spectroscopy (THz-TDS) detection point and its accurate corresponding position in pathology image. In this paper, complex human gastric tissue is taken as the experimental subject to search for accurate detection approach. This paper uses tissue microarray technology to process paraffin-embedded gastric tissue, and then contrasts the Terahertz absorption coefficient and refractive index spectrum of detection subjects which are divided into registered experimental group and unregistered control group using principal component analysis method. Meanwhile, this paper contrasts the gastric tubular adenocarcinoma THz-TDS discrimination methods using support vector machine and logistic regression respectively. The research result reveals that the detection accuracy brought by tissue microarray technology helps better discriminate tumor samples and normal samples.
[1] Ferlay J, Shin H R, Bray F, et al. Int. J. Cancer, 2010, 127(12): 2893.
[2] YANG Jia-li, Lü Ming(杨佳莉, 吕 铭). World Health Digest(中外健康文摘), 2012, 9(19): 78.
[3] Wahaia F, Kasalynas I, Seliuta D, et al. Journal of Molecular Structure, 2014, 1079: 391.
[4] Yngvesson S K, Peter B S, Siqueira P, et al. Proceedings of SPIE, 2012, 8221: 82210N.
[5] Wahaia F, Valusis G, Bernardo L M, et al. Journal of Molecular Structure, 2011, 1006: 77.
[6] Hou D, Li X, Cai J, et al. Physics in Medicine & Biology, 2014, 59(18): 5423.
[7] Chen H, Ma S, Wu X, et al. Journal of Biomedical Optics, 2015, 20(3): 36017.
[8] Ji Y B, Park C H, Kim H, et al. Biomedical Optics Express, 2015, 6(4): 1398.
[9] Goryachuk A A, Khodzitsky M K, Borovkova M A, et al. Journal of Physics Conference Series, 2016.
[10] Frederick L G M D, David L P M D, Irvin D F M D, et al. AJCC Cancer Staging Manual. AJCC Cancer Staging Manual. Springer, 2010. 803.
[11] “Gastric Cancer Molecular Fractal and Individualized Diagnosis” in the National “863” Major Project(国家“863”重大项目“胃癌分子分型与个体化诊疗”课题组). World Health Digest(中外健康文摘), 2010, 39(4): 266.
[12] Dancau A M, Simon R, Mirlacher M, et al. Methods in Molecular Biology, 2016, 1381：53.
[13] Barrette K, Oord J J V D, Garmyn M. Journal of Investigative Dermatology, 2014, 134(9): e24.
[14] Liu Z, Li X, Yue F H, et al. Advanced Materials Research, 2013, 718-720: 1060.
[15] Duvillaret L, Garet F, Coutaz J L. IEEE Journal of Selected Topics in Quantum Electronics, 1996, 2(3): 739.
[16] Dorney T D, Baraniuk R G, Mittleman D M. Journal of the Optical Society of America A-Optics Image Science and Vision, 2001, 18(7): 1562.
[17] Kamson D O, Mittal S, Buth A, et al. Molecular Imaging, 2013, 12(5): 327.
[18] Bowman T, Wu Y, Gauch J, et al. Journal of Infrared Millimeter & Terahertz Waves, 2017, 38(6): 766.
[19] Wahaia F, Kasalynas I, Venckevicius R, et al. Journal of Molecular Structure, 2016, 1107: 214.
[20] Cheon H, Yang H J, Son J H. IEEE Journal of Selected Topics in Quantum Electronics, 2017, 23(4): 8600109.
[21] Grootendorst M R, Fitzgerald A J, Sg B D K, et al. Biomedical Optics Express, 2017, 8(6): 2932.
[22] Platt J C. Advances in Large Margin Classifiers, 2000, 10(4): 61.
