光谱学与光谱分析 |
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A Silicon Phthalocyanine Axially Substituted by Nipagin: Synthesis, Molecular Spectroscopic Properties, and in vitro Photodynamic Activities |
ZHANG Guo-cai1, HUANG Jian-dong1*, CHEN Yan-mei1, SUN Jian-cheng2, LIU Hong1, CHEN Nai-sheng1, HUANG Jin-ling1 |
1. Department of Chemistry, Institute of Research on Functional Materials, Fuzhou University, Fuzhou 350002, China 2. Pharmacology Research Section, Department of Pharmacy, Fujian Medical University, Fuzhou 350004, China |
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Abstract A new silicon phthalocyanine axially substituted by Nipagin, i.e. bis(4-methoxycarboxyl phenoxy)phthalocyaninatosilicon, has been synthesized and characterized by IR, NMR, HPLC and elemental analysis. Its electronic absorption spectra and fluorescence spectra in different solvents were investigated. It was found that the compound existed in the form of monomer in a saline solution containing 2%(φ) Cremophor EL and 20%(φ) propanediol. The electronic absorption spectra of the compound in the above saline solution were typical for non-aggregated phthalocyanines, showing an intense and sharp Q band at 683 nm with a molar absorption coefficient of 7.47×104 mol-1·L·cm-1. The compound exhibited a relatively strong fluorescence emission at 690 nm with a quantum yield of 0.34 and with a fluorescence lifetime of 4.7 ns. The primary in vitro assay showed the compound had photodynamic killing activities against B16 melanoma cells with a LD50(half lethal dose) of 1.2×10-4 mol·L-1.
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Received: 2004-04-06
Accepted: 2004-08-08
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Corresponding Authors:
HUANG Jian-dong
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Cite this article: |
ZHANG Guo-cai,HUANG Jian-dong,CHEN Yan-mei, et al. A Silicon Phthalocyanine Axially Substituted by Nipagin: Synthesis, Molecular Spectroscopic Properties, and in vitro Photodynamic Activities[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2005, 25(10): 1622-1626.
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URL: |
https://www.gpxygpfx.com/EN/Y2005/V25/I10/1622 |
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