| 光谱学与光谱分析 |
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| The Study on the Far-FTIR and THz Spectra of Azitromycin Drugs with Different Physical Forms |
| YANG Yu-ping1, FAN Li-jie1, 3, CUI Bin1, CHEN Gen-xiang1, ZHANG Zhen-wei2*, ZHANG Cun-lin2 |
1. School of Science, Minzu University of China, Beijing 100081, China
2. Beijing Key Laboratory for Terahertz Spectroscopy and Imaging, Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Department of Physics, Capital Normal University, Beijing 100048, China
3. School of Electronic and Information Engineering, Beijing Jiaotong University, Beijing 100044, China |
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Abstract Far Fourier transform infrared spectroscopy (Far-FTIR) and terahertz time-domain spectroscopy (THz-TDS) were used to measure the fingerprint spectra of Azitromycin suspension, capsule, tablet and dispersible tablet under vacuum and nitrogen conditions, respectively. In the frequency range of 0.2～15 THz, highly resolved spectral features for Azitromycin suspension were measured and some minor differences were observed between domestic and exotic Azitromycin Suspension, such as linewidth broadening and additional peaks. As same time, for the domestic Azitromycin capsule, tablet and dispersible tablet, the absorption baselines in the range of 0.2～2.7 THz rise with the increase of frequency while absorption peaks become weaker due to the scattering of bigger particles and smaller amount of Azitromycin. Also, the additional peaks are caused by the absorption of filling materials. In parallel with the qualitative measurement, the THz absorption spectra for mixtures of polyethylene (PE) powders and exotic Azithomycin suspension with different concentrations were also measured. According to the linear correlation between the concentration and the absorption intensity, the concentration of effective component can be evaluated accurately. This means that THz-TDS method is suitable for the quality inspection and evaluation of the mixed Azithromycin system.
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Received: 2014-06-12
Accepted: 2014-10-22
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Corresponding Authors:
ZHANG Zhen-wei
E-mail: zhangzw_cnu@163.com
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