光谱学与光谱分析 |
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Identification of Metoprolol Tartrate Tablets from Different Manufacturers by Different Near Infrared Spectrometers |
LI Qi-lu1, WANG Fei2, WANG Jin-feng2, ZANG Heng-chang2*, ZHANG Hui3, JIANG Wei2 |
1. School Infirmary, Shandong University, Ji’nan 250012, China 2. School of Pharmaceutical Sciences, Shandong University, Ji’nan 250012, China 3. Beijing Kaiyuan Shengshi Sciencce and Technology Development Co., Ltd., Beijing 100081, China |
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Abstract To rapidly identify Metoprolol Tartrate tablets from different manufacturers, a qualitative analysis model can be established by near infrared spectroscopy. Firstly, AntarisII Fourier-transform near infrared (FT-NIR) spectroscopy and Micro NIR1700 Spectrometer were used to collect spectral data of 66 batches of samples which come from four different manufacturers, then 44 samples of calibration set and 22 samples of validation set were acquired by random sampling. In order to build up a PLS-DA model, the first derivative with Savitzky-Golay 15 points smoothing (1d+SG15) and standard normal vitiate transformation (SNV) was selected as the pretreatment method and according to the variation between different samples and the characteristic absorption band, 6 468~7 104 cm-1 and 6 468~7 156 cm-1 were chosen as the modeling spectra region. The confusion matrix indicated that Metoprolol Tartrate tablets could be rapidly and effectively identified by two analytical models, which were established using the spectral data collected from two instruments. For these two models, both of the sensitivity and specificity were 100%. This study confirmed that it is feasible to carry out the manufacturer identification of Metoprolol Tartrate tablets by near infrared spectroscopy. Besides, the use of Micro NIR1700 Spectrometer, which is the minimum and portable near infrared spectrometer, provides valuable insights for fast on-site drug screening.
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Received: 2014-06-06
Accepted: 2014-10-25
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Corresponding Authors:
ZANG Heng-chang
E-mail: zanghcw@126.com
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