| 光谱学与光谱分析 |
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| Development and Application of Six-Channel Fiber Optic Sensing Drug Dissolution Monitor |
| YAO Jun1, SHEN Jing2*, LI Li1*, LI Xin-xia1, CHEN Jian1 |
1. College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China
2. Department of Pharmacy, The Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China |
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Abstract The drug dissolution test is an important examination of drug testing, which plays a very important role in the drug quality assessment. Automation and proceduring monitoring of drug dissolution can be implemented by the optical fiber sensing technology. Two modes of detection of UV-Vis absorption and fluorescence quenching were established by software implementation, with xenon lamp, deuterium lamp or halogen tungsten lamp as fluorescence, UV and visible light source, branch Y type optical fiber as light path transmission medium, UV-Vis probe and fluorescence molecular probe as light response devices, and CCD as detector. Optical fiber sensing drug dissolution monitor not only solves the current problems of time-consuming, and sampling of off-line analysis, but also provides real-time information of drug dissolution process. Thus, our study may provide a better evaluation method for the drug quality control.
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Received: 2013-09-04
Accepted: 2013-12-21
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Corresponding Authors:
SHEN Jing, LI Li
E-mail: shenjing77@aliyun.com;llxjmu@163.com
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