光谱学与光谱分析 |
|
|
|
|
|
Study on the Inclusion Compound of Avermectin by Infrared Spectroscopy |
SHEN Wen1*,ZHANG Guang-hua2,GUO Ning2,LI Yun-tao2 |
1. College of Life Science and Engineering, Shaanxi University of Science and Technology, Xi’an 710021, China 2. College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi’an 710021, China |
|
|
Abstract This study was designed to investigate the formation and effect of inclusion complex of Avermectin-β-cyclodextrin based on the accommodation property of β-cyclodextrins molecular cavity. The inclusion complex of Avermectin-β-cyclodextrin was prepared using saturated solution method and high performance liquid chromatography (HPLC) was employed to determine its entraping efficiency. The formation of Avermectin-β-cyclodextrin inclusion complex was also demonstrated by infrared spectroscopy(IR). The change of chemical structure produced by photocatalysis of Abamectin was analyzed and the effect of inclusion complex to strengthen the photolysis stability of Abamectins chemical structure was studied. The results show that the entraping efficiency of the inclusion complex was 40.5%. The IR analysis presents that the intermolecular hydrogen bond was formed in the Avermectin-β-cyclodextrin inclusion complex, indicating the composition effect was different from physical mixture. The lactones structure of Avermectin B1a can be photodecomposed and disrupted. After decomposition, the infrared stretching vibration peak of C—O—C structure disappeared and the lactone bond was significantly broken. The lactones structure of avermectin B1a was covered by the inclusion molecular loci in β-cyclodextrin after the formation of avermectin-β-cyclodextrin inclusion complex, providing a good photophobic protection for C—O—C structure in the macrocyclic lactone structure of avermectin B1a and improving the photostability of avermectin B1a molecule. The innovation of this study is that the structure and the characters of the prepared avermectin-β-cyclodextrin inclusion complex were analyzed using spectrum methods. This inclusion complex is expected to be the ideal intermediate in the construction of protective controlled release formulation of avermectin.
|
Received: 2013-07-11
Accepted: 2013-11-22
|
|
Corresponding Authors:
SHEN Wen
E-mail: 285248300@qq.com
|
|
[1] Awasthi Atul, Razzak Majid, Al-Kassas Raida, et al. Chemical and Pharmaceutical Bulletin, 2012,60(8):931. [2] JIN Zheng-yu, XU Xue-ming, CHEN Han-qing, et al(金征宇, 徐学明, 陈寒青, 等). Cyclodextrin Chemistry:Preparation and Application(环糊精化学:制备与应用). Beijing: Chemical Industry Press(北京:化学工业出版社), 2009. 17. [3] Yan Yunfeng, Hou Hongwei, Ren Tianrui, et al. Colloids and Surfaces B-Biointerfaces,2013,102(2):341. [4] Srinivasan K, Stalin T, Shanmugapriya A, et al. Journal of Molecular Structure, 2013, 1036(3):494. [5] Jeetendra Singh Negi, Shivpal Singh. Carbohydrate Polymers, 2013, 92(2): 1835. [6] Manivannan C, Vijay R Solomon, Venuvanalingam P, et al. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2013, 103(2):18. [7] Paula P Menezes, Mairim R Serafini, Bruno V Santana, et al. Thermochimica Acta, 2012, 548(11): 45. [8] Hu Liandong, Zhang Hailei, Song Weihua, et al. Carbohydrate Polymers, 2012, 90(4):1719. [9] Antony A Muthu Prabhu, Subramanian V K, Rajendiran N. Spectrochimica Acua Part A: Molecular and Biomolecular Spectroscopy,2012, 96(10):95. [10] Srinivasan K, Stalin T, Sivakumar K. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2012, 94(8):89. [11] Chowdary K, Raga P R, Sunil Raga. Asian Journal of Chemistry, 2012,24(8): 1693. [12] BAI Lei, SONG Le-xin, WANG Mang, et al(柏 雷,宋乐新,王 莽,等). Chinese Journal of Chemical and Physics(化学物理学报), 2010, 23(1): 117. |
[1] |
YAN Kang-ting1, 2, HAN Yi-fang1, 2, WANG Lin-lin1, 2, DING Fan3, LAN Yu-bin1, 2*, ZHANG Ya-li2, 3*. Research on the Fluorescence Spectra Characteristics of Abamectin Technical and Preparation Solution[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(11): 3476-3481. |
[2] |
ZHOU You, TAN Hong-peng, TANG Shuang, HU Zhen-ping, LIANG Jian-gong, REN Guo-lan*. Study on the Photostability of Histidine and Glutathione Modified Gold Nanoclusters[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2018, 38(10): 3177-3181. |
[3] |
GUAN Xue-li, FU Ji-hong, TANG Jun1* . Study on the Release Process for Lavender Essential Oil Microcapsule by FTIR [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2017, 37(01): 65-69. |
[4] |
SHI Dong-po, YIN Xian-qing, ZHENG Yan-cheng, CHEN Wu, FU Jia-xin, ZOU Hua, REN Zhao-hua. HP-β-CD Reduced the Interference of the Micellization on Spectrum Quantitative Analysis of SDBS in Oilfield Water[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2016, 36(06): 1803-1808. |
[5] |
FENG Gang1, 2, PING Wen-hui1, ZHU Xia-shi1* . Fe3O4-β-Cyclodextrin Polymer Nano Composites Solid-Phase Extraction-UV-Vis Spectrophotometry for Separation Analysis Malachite Green[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2016, 36(02): 436-441. |
[6] |
SHI Dong-po, YIN Xian-qing, ZHENG Yan-cheng, CHEN Wu, FU Jia-xin, REN Zhao-hua . Study on Quantitative Mechanism and the Interference of the UV Spectrum of HABS Reduced by β-Cyclodextrin[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2014, 34(09): 2460-2465. |
[7] |
SHI Dong-po, YIN Xian-qing, ZHENG Yan-cheng, CHEN Wu, FU Jia-xin, REN Zhao-hua . Study on the Enhanced Spectrum Quantitative Analysis of SDBS Induced by β-Cyclodextrin [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2013, 33(08): 2163-2167. |
[8] |
ZHAO Meng-qi, Nurulla Ismayil* . Synthesis of Crosslinked Polymer Containing β-Cyclodextrin and Its Adsorption for Pb2+ and Zn2+ Studied by AAS[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2013, 33(08): 2219-2222. |
[9] |
WANG Da-wei1,2, LIU Qi3,4, LIU Ming2, LIU Xiao-hui1* . The Preparation, Characterization and Ultraviolet Photodegradation of LNG-HP-β-CD [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2011, 31(03): 808-811. |
[10] |
LI Qian-qian, ZHU Ye-wei, XIONG Yan-mei, DUAN Jia, WU Li-jun, LI Chun-zi, MIN Shun-geng* . Fast Determination of the Proportion of Metalaxyl-M Enantiomers by UV Spectroscopy [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2010, 30(12): 3395-3398. |
[11] |
CHEN Yuan-yuan1,LIU Jia-jia1,TANG Ke-wen1,2. Study on Inclusion Complexes of β-Cyclodextrin with Zopiclone[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2008, 28(10): 2380-2383. |
[12] |
XIAO Yu-mei,WU Yan-hua,LIU Ji-ping,LI Yan-fang,LI Nan*,QIN Zhao-hai*. Study on the Molecular Recognization of Fungicide of Kresoxim-Methyl with β-cyclodextrin and Its Derivatives[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2008, 28(10): 2370-2374. |
[13] |
TONG Xiao-qing1,2,Lü Jian-quan1*,SUN Juan1,GONG Zhong-hong1 . Fluorescence and Visible Spectroscopic Studies on Interaction of β-Cyclodextrin-Thionine Inclusion Complex with DNA[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2007, 27(12): 2538-2541. |
[14] |
CHEN Xiao-yan, LIU Wan-yi*, ZHANG Jing. Study on the Characterization of β-Cyclodextrin-Diferrocenylenone Inclusion Complex and Micro-Environmental Effects[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2006, 26(07): 1285-1289. |
[15] |
ZHANG Jing, LIU Wan-yi*,ZHANG Xia. Study on the Characterizations of β-Cyclodextrin-Benzoylferrocene- Thiosemicarbazone Inclusion Complex and Micro-Environmental Effects[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2006, 26(03): 517-521. |
|
|
|
|