| 光谱学与光谱分析 |
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| Anti-HepG-2 Cell Properties of Rare Earth Tungstosilicic Polyoxometalates Containing 5-Fluorouracil |
| LIU Xia1, WANG Shuai-shuai2, FENG Chang-gen2 |
1. College of Science, China Agricultural University, Beijing 100193, China
2. School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, China |
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Abstract Two novel rare earth tungstosilicic polyoxometalate containing 5-fluorouracil, K26(C4H4FN2O2)8Pr(SiW11O39)4·10H2O (FPSW) and K26(C4H4FN2O2)8Sm(SiW11O39)4·9H2O (FSSW), were synthesized and their structure were characterized by using elemental analysis, FTIR spectra, X-ray powder diffraction and TG. The antitumor activity tests of the compounds FPSW and FSSW were carried out by the methyl thiazolyl tetrazolium method in hepatocellular carcinoma cell HepG-2. The results showed that FPSW and FSSW could inhibit the HepG-2 cells in vitro significantly. The EC50 of FPSW and FSSW is 1.94×10-5 and 1.32×10-5 mol·L-1 respectively. The therapeutic index of FPSW and FSSW is 0.76 and 1.58 respectively.
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Received: 2012-06-20
Accepted: 2012-08-21
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Corresponding Authors:
LIU Xia1
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