| 光谱学与光谱分析 |
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| Preparation and Performance of Controlled-Release Tablets of Sasanquasaponin-Casein |
| LIU Xiao-zhen1, YANG Jun-hua1, SONG Ling-ling2, SONG Yue-xing1, LAI Zhong-fan3, ZHAI Li1 |
1. School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 200235, China
2. The University Hospital, Gannan Normal University, Ganzhou 341000, China
3. Department of Pharmacology and Molecular Therapeutics, Graduate School of Medical Sciences, Kumamoto University Kumamoto University, Kumamoto 860-8555, Japan |
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Abstract The controlled-release tablets of sasanquasaponin (SQS)-casein were prepared by using SQS, casein and guar gum as the main drug and accessory materials respectively. The method of determination of SQS in the controlled-release tablets of SQS-casein, and the effects of release media on the release rate and IR spectra of the controlled-release tablets of SQS-casein were studied, respectively. The release rate curve of the controlled-release tablets of SQS-casein was fitted as zero order, one order and Higuchi equation. The recovery was 98.59% when the content of SQS in the controlled-release tablets of SQS-casein in phosphate buffer solution (pH 6.8) as release media was determined with chromogenic reaction of vanillin- sulfuric acid. The release rates are 23.80%, 51.26% and 94.77% at release times 3, 6 and 12 h, respectively in phosphate buffer solution (pH 6.8) as release media. The controlled-release tablets of SQS-casein release SQS by slowness and constant in 12 h. The chemical bonds are formed among SQS, casein and guar gum.
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Received: 2011-12-27
Accepted: 2012-03-18
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Corresponding Authors:
LIU Xiao-zhen
E-mail: liuxiaozhen1958@yahoo.com
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