| 光谱学与光谱分析 |
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| Initial Research on Fourier Transform Infrared Spectroscopy for the Diagnosis of Colon Neoplasms |
| YAO Hong-wei1, LIU Ya-qi1, FU Wei1, SHI Xue-ying2, ZHANG Yuan-fu3, XU Yi-zhuang3* |
1. Department of General Surgery, Peking University Third Hospital, Beijing 100191, China
2. Department of Pathology, Peking University Health Science Center, Beijing 100191, China
3. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China |
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Abstract To explore the feasibility of Fourier transform infrared spectrometry (FTIR) for the diagnosis of colon neoplasms, fresh samples of eighteen cancers and ten adenomas were collected during colon surgery and were measured by FTIR via probe of attenuated total reflection (ATR). The peak position and the intensity of all bands were measured and compared between the malignant and benign groups. Results show that the FTIR of malignant neoplasm was different from that of benign one. (1)For the bands related to lipid: The ratio of I2 925/I1 460(p=0.018) and I1 740/I1 460(p=0.009) decreased in cancer FTIR spectrum, indicating the lower relative quantity of lipid in malignant neoplasm. (2)For the bands related to protein: The ratios of I3 375/I1 460(p=0.012) and I1 550/I1 460(p=0.041) increased in cancer, which shows that the relative quantity of protein was more in cancer than that in adenoma. (3) For the band related to nucleic acid: In malignant tissue the peak position in 1 080 cm-1 shifted toward a higher wave number (p=0.039), compared with that in benign one. And the ratio of I1 083/I1 460 increased significantly (p=0.036), illustrating the higher relative quantity of nucleic acid to lipids in malignancy. (4) The peak position of 1 305 cm-1 shifted to a lower wavenumber (p=0.041), which should be determined in further research. It is concluded that our initial research showed that the FTIR maybe develops into a promising method for rapid differential diagnosis of colon malignant and benign neoplasms.
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Received: 2010-05-10
Accepted: 2010-08-20
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Corresponding Authors:
XU Yi-zhuang
E-mail: xyz@pku.edu.cn
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[4] Michael J W, Matthew J G, Maneesh S H M, et al. Cancer Letters, 2007, 246(1): 1.
[5] LIU Ya-qi, GAO Mei-juan, XU Yi-zhuang, et al (刘亚奇, 高梅娟, 徐怡庄, 等). Spectroscopy and Spectral Analysis(光谱学与光谱分析), 2009, 29(11): 2917.
[6] LING Xiao-feng, XU Yi-zhuang, WANG Li-xin, et al(凌晓锋, 徐怡庄, 王立新, 等). Chemical Journal of Chinese Universities(高等学校化学学报), 2007, 28(3): 445.
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