| 光谱学与光谱分析 |
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| Spectrum Analysis Methods of Protein Adsorption and Design of Biomedical Materials |
| XU Dong1, 2, ZHOU Ning-lin1, 2, 3*, SHEN Jian1, 2, 3 |
1. Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing 210097, China
2. Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Environmental Science, Nanjing Normal University, Nanjing 210097, China
3. Jiangsu Technological Research Center for Interfacial Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
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Abstract Protein absorption happens firstly when biological materials contact environment of organisms. The competitive adsorption behavior of different protein and the impact of biomaterial surfaces characteristics on protein adsorption are summarized. Materials with small surface free energy, high hydrophility, and a negative charge, or with the presence of micro-phase separation structure are able to reduce fibrinogen adsorption, showing good anti-clotting properties. FTIR, CD, NMR and FL are applied in protein adsorption analysis. XPS, Raman, AFM and other modern instruments have also emerged in this area. QCM appears to be more intuitive in the study of protein adsorption mechanism. The development of study on protein adsorption would guide the design of biomedical materials.
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Received: 2010-05-10
Accepted: 2010-08-20
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Corresponding Authors:
ZHOU Ning-lin
E-mail: zhouninglin@njnu.edu.cn
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