| 光谱学与光谱分析 |
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| Studies on Ru(bipy)2dppx2+ as Interacting Mode Spectroscopic Probe of DNA |
| CHEN Fang1，2, HE Zhi-ke1* |
1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China
2. Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China |
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Abstract The interacting mode of adriamycin with DNA has been studied by the use of molecular “light switch" complex Ru(bipy)2dppx2+ as a interacting mode spectroscopic probe. The results of the influence of ADM on the fluorescence and Scatchard equation of Ru(bipy)2dppx2+-DNA system indicate that ADM intercalates the base pairs of DNA. Compared with normal DNA interacting mode spectroscopic probe EB, Ru(bipy)2dppx2+ has the advantages of higher sensitivity, lower toxicity, higher stability and simplicity.
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Received: 2004-05-28
Accepted: 2004-10-13
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Corresponding Authors:
HE Zhi-ke
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| Cite this article: |
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CHEN Fang,HE Zhi-ke. Studies on Ru(bipy)2dppx2+ as Interacting Mode Spectroscopic Probe of DNA [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2005, 25(12): 2052-2055.
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https://www.gpxygpfx.com/EN/Y2005/V25/I12/2052 |
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