|
|
|
|
|
|
Preparation and Spectroscopic of Vanadyl(Ⅱ) Vitamin D3 Amino Acid Mixed Complexes as Insulin Mimetic Drug |
Enas Aljuhani1, Amnah M. A. Alsuhaibani2, A. M. El-Didamony3, N. Hassan4, Sameh Abo Taleb4, Moamen S. Refat4,5* |
1. Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah, P.O.9168 Zip Code 21955, Saudi Arabia
2. Nutrition and Food Sciences Dept., Home Economic College, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
3. Department of Chemistry, Faculty of Science, Zagazig University, Egypt
4. Department of Chemistry, Faculty of Science, Port Said, Port Said University, Egypt
5. Chemistry Department, Faculty of Science, Taif University, P. O. Box 888, Al-Hawiah, Taif 21974, Saudi Arabia |
|
|
Abstract A new six intraperitoneal injection insulin-mimetic vanadyl(Ⅱ) compounds [(VD-13)(VO+2)(AA-1n)] (where (n=1~6); AA1=isoleucine, AA2=threonine, AA3=proline, AA4=phenylalanine, AA5=lysine and AA6=glutamine) were synthesized by the chemical reactions between vitamin D3 (VD3), VOSO4 and amino acids (AAn) with equal molar ratio 1∶1∶1 in neutralized media. The structures of these complexes were elucidated by spectroscopic methods like, infrared and solid reflectance spectroscopes. Magnetic moments and electronic spectra reveal square pyramid geometrical structure of the complexes. The infrared spectra assignments of these complexes revealed that the chelation towards vanadyl(Ⅳ) ions existed via deprotonation of the hydroxyl group of VD3 drug ligand and so amino acids act as bidentate ligand via N-amino and O-carboxylate groups. The anti-diabetic efficiency of these complexes were evaluated against streptozotocin induced diabetic male albino rats.
|
Received: 2018-10-25
Accepted: 2019-02-18
|
|
Corresponding Authors:
Moamen S. Refat
E-mail: msrefat@yahoo.com
|
|
[1] Zhang H, Yi Y, Feng D, et al. Evidence Based Complement Altern Med., 2011, 69(1): 67.
[2] Thompson K H, Orvig C. Coord. Chem. Rev.,2001,219-221:1033.
[3] de la Monte S M. Endocrinology and Metabolism Clinics of North America,2014,43(1):245.
[4] Harper E, Forde H, Davenport C, et al. Vascular Pharmacology,2016,82:30.
[5] Ibrahim.M A, Habila J D, Koorbanally N A, et al. J. Ethnopharmacology, 2016, 183: 103.
[6] Macdonald H M, Mavroeidi A, Reid D M,et al. Br. J. Dermatol.,2010,163: 434.
[7] Miller J,Gallo R L. Dermatol. Ther., 2010, 23: 13.
[8] Parfitt A M, Han Z H, Palnitkar S, et al. J. Bone Miner. Res., 1997, 12: 1864.
[9] Chiu K C, Chu A, Go V L, et al. Am. J. Clin. Nutr., 2004, 79: 820.
[10] Hounsom L, Horrobin D, Tritschler H, et al. Diabetologia, 1998, 41(7): 839.
[11] Hussain A M. Am. En. J. Med. Sci., 2011, 4(1): 84.
[12] Hajduch E, Darakhshan F, Hundal H. Diabetologia, 1998, 41(7): 821.
[13] Siddiqui M R, Taha A, Moorthy K, et al. J. Biosci.,2005,30(4):101.
[14] Sanford H S. Science,1954,119:100.
[15] Woodhead O, Otton P, Spake L. Clin. Pharmacol., 1974, (21): 11.
[16] Carleton H M. Carleton’s Histological Technique, fourth ed., Oxford University Press, London, New York, Toronto, 1967.
[17] Snedecor G W, Cochran W G. Statistical Methods, eighth ed., Ames Iowa State University, 1982.
[18] Refat M S. J. Mol. Struct., 2007, 842(1-3): 24.
[19] Lever A B P. Inorganic Electronic Spectroscopy, Elsevier, Amsterdam, The Netherlands, 1986.
[20] Valentina U, Stefania Felicia B, Victoria A, et al. Molecules, 2010,15:1578.
[21] Nakamoto K. Infrared Spectra of Inorganic and Coordination Compounds, Wiley Interscience, New York, 1970.
[22] Nakamato K, Mc Carthy P J. Spectroscopy and Structure of Metal Chelate Compounds, John Wiley, New York, 1968. 268.
[23] Soliman A,Linert W. Thermochim. Acta,1997,338:67.
[24] Mohamed G G, Zayed M A, Nour El-Dien F A,et al. Spectrochim. Acta A, 2004, 60:1775.
[25] Bhattacharyya S, Mukhopadhyay S, Samanta S, et al. Inorg. Chem., 2002,41:2433.
[26] Miyauchi1 A, Okabe T H. Materials Transactions, 2010,51(6):1102.
[27] Motkar G, Lonare M, Patil O. S. Mohanty, 2013,59(4):1360.
[28] Cullity B D. Elements of X-ray Diffraction. Addison-Wesley Publication Company, Massachusetts, 1978.
[29] Punitha I, Shirwaikar A. Diabetol. Croat., 2005, 34: 117.
[30] Braunwald. Evaluation of Liver Function. in: E. Braunwald, et al. (Eds.), Harrison’s Principles of Internal Medicine. McGraw-Hill, New York, 2001. 1711.
[31] Ganong W. Review of Medical Physiology, Lange Medical Books, Vol. 13, McGraw-Hill, New York, 2003. 912.
[32] Edwards N L. Crystal Deposition Diseases, in: Goldman L, Schafer A I (Eds.). Cecil Medicine, 24th ed., Saunders Elsevier, Philadelphia, PA, 2011. 281.
[33] Butt A A, Michaels S, Greer D, et al. AIDS Read, 2002, 12(7): 317.
[34] Zhang J, Steele M, Schweiger A. Geophys Res. Lett., 2010,37: 205.
[35] Ugochukwu N H, Babady N E. Life Sci., 2003, 73: 1925.
[36] Prabu K A, Kumarappan C T, Christudas S, et al. Trop. Biomed., 2012. 31.
[37] Rajasekaran S, Sivagnanam K, Subramanian S. Pharmacology,2005,57:185.
[38] Pushparaj P, Tan C, Tan B. J. Ethnopharmacol., 2000, 72: 69.
[39] Toshio M, Mika F, Tetsuo M, et al. Biol. Pharm. Bull., 1998, 21(9): 889.
[40] Levy E, Bendayan M. Diabete Metab., 1991, 17: 44.
[41] Subash P B, Prabuseenivasan S, Ignacimuthu S. Phytomedicine, 2007, 14: 15. |
[1] |
Moamen S. Refat1*, Mahmoud Salman2, Akram M. El-Didamony3, Hammad Fetooh3, Eman S.E. Abd El-Maksoud3,Mohamed Y. El-Sayed3,4. Spectroscopic and Fluorescence Studies on the Trivalent Ce, Eu, Nd and La Metal Ions Rhodamine C Florescent Dye Complexes[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(10): 3311-3315. |
[2] |
Samy M. El-Megharbel1,2*,Moamen S. Refat1,3. Synthesis and Spectroscopic Characterizations of New Mercury(Ⅱ), Cerium(Ⅲ), and Thorium(Ⅳ) Captopril Drug Complexes[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(11): 3649-3652. |
[3] |
Samy M El-Megharbel1,2*, Tariq Altalhi1, Abdullah Ayad Salem Alruqi3, Moamen S Refat1,4. Synthesis and Spectroscopic Characterizations on the Complexation of Three Different Metal Ions Ba(Ⅱ), Ni(Ⅱ), and Ce(Ⅲ) with Atenolol Drug Chelate[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(06): 1988-1992. |
[4] |
Moamen S. Refat1,2*, Abeer A. El-Habeeb3. Synthesis, Spectroscopic and Antimicrobial Investigations of Scandium(Ⅲ) Complexes with Four Kinds of Sulfa Drugs[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(03): 985-990. |
[5] |
Ahmed. I. El-Shenawy*, Ishaq. F. E. Ahmed, Moamen. S. Refat. Fabrication of Semiconductor Polymer Membranes Combined with a Colored Charge Transfer Complexes Used in the Manufacture of Solar Cells as a Source of Alternative Energy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2019, 39(07): 2307-2315. |
[6] |
Omar B. Ibrahim1, El-Sayed A. Manaaa2,3, M.M. AL-Majthoub1, Ahmed M. Fallatah1, Abdel Majid A. Adam1, Mha M. Alatibi1, Jehan Y. Al-Humaidi4, Moamen S. Refat1,5*. Estimation of Metformin Drug for the Diabetes Patients by Simple, Quick and Cheap Techniques within the Formation of Colored Charge Transfer Complexes[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2018, 38(11): 3622-3630. |
[7] |
Belal H M Hussein1,2*, Mostafa A Gouda1,3, Omer Sakin1, Abdulla Faluji4, Mohamed Gomaa5, Hassan A Azab2, Walid Fathalla6, Sherin Arabi7, Sawsan Mosa8. DNA Binding and Antitumor Activity of a New Fluorescent Probe Eu(Ⅲ)-Complex Containing 4-Methyl-Coumarin Moiety[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2018, 38(11): 3611-3621. |
[8] |
Zeynep Gedik1, Mehtap Tugrak2, Aysenur Dastan2, Halise Inci Gul2, Demet Ylmaz1* . Radiation Parameters of Some Potential Bioactive Compounds [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2015, 35(06): 1501-1505. |
[9] |
LI Zhi, ZHANG Zhao-hui*, ZHAO Xiao-yan, SU Hai-xia, YAN Fang. Extracting THz Absorption Coefficient Spectrum Based on Accurate Determination of Sample Thickness[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2012, 32(04): 1043-1046. |
[10] |
ZHU Meng-hua1, LIU Liang-gang1, ZHENG Mei2, QI Dong-xu1, ZHENG Cai-mu1 . Automatically Smoothing the Spectroscopic Data by Cubic B-Spline Basis Functions[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2009, 29(10): 2721-2724. |
[11] |
DONG Shun-fu1, LIU Jie2, SUN Xiao-li3, HAN Li-qin1, ZHAO Wen-xiu1 . Determination and Analysis of Trace Element Manganese and Amino Acids Content in Aloe Tea[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2006, 26(06): 1170-1172. |
|
|
|
|