Synthesis, Spectroscopic and Antimicrobial Investigations of Scandium(Ⅲ) Complexes with Four Kinds of Sulfa Drugs

doi:10.3964/j.issn.1000-0593(2020)03-0985-06

Abstract
References
Related Citation (9)

Download: PDF (2030 KB)
Export: BibTeX | EndNote (RIS)

Abstract Herein, this article was focused on the synthesis and discussed the spectroscopic characterizations of four new scandium(Ⅲ) sulfa-drug complexes. The nomenclature and symbols of these drugs were sulfadimidine (sulp-1), sulfanilamide (sulp-2), sulfamethoxazole (sulp-3) and sulfadiazine (sulp-4). The microanalytical and spectroscopic analyses which utilized in this study were micro-analyses, magnetic, FT-IR, UV-Vis techniques. The mid infrared spectra deduced that the four sulfa-drug chelates acts as a bidentate chelates with scandium(Ⅲ) ion via two nitrogen atoms of —NH₂-Ar and —NH-SO₂ groups. Also, the FTIR spectra of Sc³⁺ complexes referred to the existed of new medium weak bands in the range of 500～400 cm^-1 due to stretching vibration bands of ν(M—N). The elemental analysis technique confirmed the 1∶2 stoichiometry between Sc³⁺ ions and sulp ligand with molecular formula [Sc(sulp)₂(Cl)₂]·Cl. At room temperature, the results of magnetic measurements for the Sc(Ⅲ) complexes indicated that all of the synthesized complexes have a diamagnetic character with octahedral configuration. The electronic spectra of the free sulfa-drug ligands shows band at 275 and 310 nm which are intraligand charge transfer band. The electronic sbsorption spectra of the Sc³⁺ complexes were recorded using DMSO solvent. The spectra of complexes display bands within 275～388 nm, which attributed to π—π^*, n—π^* and charge-transfer M-L_CT electronic transitions, which strongly favors the octahedral geometry around Sc(Ⅲ) metal ions. ¹HNMR spectra of complexes referred to the downfield proton shifts of the —NH₂ and NHSO₂ groups, which supported the place of coordination. The half maximal inhibitory concentration (IC₅₀) of the Sc^Ⅲ complexes was assessed against the human hepato cellular carcinoma (HepG-2) tumor cell line.

Key words：Sulfa-drugs; Sc^Ⅲ; Spectroscopic; Chelation; Nano-particles; Antimicrobial

Received: 2019-08-31 Accepted: 2019-12-26

ZTFLH:

O433

Corresponding Authors: Moamen S. Refat E-mail: msrefat@yahoo.com

Cite this article:

URL:

https://www.gpxygpfx.com/EN/10.3964/j.issn.1000-0593(2020)03-0985-06 OR https://www.gpxygpfx.com/EN/Y2020/V40/I03/985

[1] Arshia F Begum, Almandil N B,et al. Bioorganic & Medicinal Chemistry, 2019，27(6)：1009.
[2] Kausar N, Muratza S, Raza M A, et al. Journal of Molecular Structure, 2019，1185：8.
[3] Barnhart E R(Ed.). Physician_s Desk Reference, PDR, 43rd ed., Medical Economics, New York, 1989.
[4] García-Raso A, Fiol J J, Rigo S, et al. Polyhedron，2000，19：991.
[5] Alzuet G, Ferrer-Llusar S, Borrs J, et al. J. Inorg. Biochem., 1999, 75: 189.
[6] Scozzafava A, Menabuoni L, Mincione F, et al. J. Med. Chem.，1999，42：2641.
[7] Briganti F, Scozzafava A, Supuran C T. Eur. J. Med. Chem.，1997，32：901.
[8] Fox C L, Modak S, Stanford J W, et al. Scand. J. Plast. Reconsre. Surg.，1979，13(1)：89.
[9] Lippincott J P. Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry, (8th Edn); Philadelphia, 1982. 162.
[10] Srivastava S P, Gupta V K, Gupta K, et al. Synth. React. Inorg. Met.-Org. Chem., 1987，17(8-9)：801.
[11] Gu S X, Deng R W, Wu J G. Chem. J. Chin. Univ., 1987，8(7)：575.
[12] Gupta J K, Jha N K. Ind. J. Chem., 1987，26A：529.
[13] Kanagaraj G, Rao G N. Ind. J. Chem., 1993，32A：594.
[14] Abd El-Wahed M G, El-Megharbel S M, El-Sayed M Y, et al. Bulg. Chem. Commun., 2015，47(3)：895.
[15] Koumarianou E, Loktionova N S, Fellner M, et al. Applied Radiation and Isotopes, 2012，70：2669.
[16] Bauer A W, Kirby W A, Sherris C, et al. Am. J. Clin. Pathology, 1996，45：493.
[17] Mosmann T. J. Immunol. Methods, 1983，65：55.
[18] Refat M S. J. Mol. Struct., 2007, 842(1-3): 24.
[19] Cotton S A. Polyhedron, 1999，18：1715.
[20] Nakamoto K. Infrared Spectra of Inorganic and Coordination Compounds, Wiley Interscience, John Wiley & Sons, New York, NY, USA, 2nd edition, 1970.
[21] Chittilappilly P S, Yusuff K K M. Indian J. Chem., 2008, 47A: 848.
[22] Dharmaraj N, Viswanathamurthi P, Natarajan K. Trans. Met. Chem., 2001，26：105.