| 光谱学与光谱分析 |
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| Study on Brain Tissue Characteristics of Rat Model of Parkinson’s Disease Based on Functionality Near-Infrared Spectroscopy (fNIRs) Technology |
| HU Guang-xia1, QIAN Zhi-yu1*, SUN Tao2, YANG Tian-ming3, WANG Wen-hong3 |
1. Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China
2. Department of Neurosurgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China
3. Department of Neurosurgery, Zhongda Hospital, Southeast University, Nanjing 210009, China |
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Abstract Functionality near infrared spectroscopy(fNIRs) technology was utilized in the present paper to explore functional properties of brain tissue of rat model of Parkinson’s disease(PD). Imaging data of rat model were detected by small animal MRI and CT; and characteristic parameters of striatum of rat brain were detected by fNIRs system. Experimental results show that, between PD and normal rat, there is no obvious change in morphological structure, but significant differences existed in reduced scattering coefficient (μ′s) and cerebral blood volume(CBV) of rat striatum; there exists correlation between parameters(μ′s, CBV) obtained by fNIRs and parameters (cerebral blood flow(CBF), CBV) obtained by CT perfusion(CTP). These results indicate that fNIRs can be used as important reference for PD research.
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Received: 2009-12-06
Accepted: 2010-03-09
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Corresponding Authors:
QIAN Zhi-yu
E-mail: zhiyu@nuaa.edu.cn
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