光谱学与光谱分析 |
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Molecular Imprinting-Flow Injection Chemiluminescence Method for Determination of Doxycycline Hydrochloride |
ZHOU Yan-mei1, ZHANG Cheng-li1, LEI Jian-du2, MA Tong-sen1, MA Guang-hui2, SU Zhi-guo2, CHAO Yang1 |
1. College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China 2. National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, China |
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Abstract Doxycycline hydrochloride can enhance the chemiluminescence of potassium ferricyanide and luminol in alkaline medium. So a molecular imprinting-flow-injection chemiluminescence method for the determination of doxycycline hydrochloride was established by using doxycycline hydrochloride-imprinted polymers as recognition material and potassium ferricyanide and luminol as detection system. Doxycycline hydrochloride-imprinted polymer was synthesized using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as cross-linker. The linear range is 9.0×10-7-6.0×10-5 g·mL-1 and the detection limit is 3.2×10-7 g·mL-1. The relative standard deviation for 6.0×10-6 g·mL-1 of doxycycline hydrochloride was 3.5% (n=9). This method has been successfully applied to the determination of doxycycline hydrochloride in tablets and in urine samples.
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Received: 2008-08-10
Accepted: 2008-11-20
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Corresponding Authors:
ZHOU Yan-mei
E-mail: zhouym@henu.edu.cn,zhouymhd@163.com
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