便携式X射线荧光光谱快速无损分析牛黄清心丸(局方)中汞、砷含量及均匀度

doi:10.3964/j.issn.1000-0593(2017)10-3225-04

Abstract
References
Related Citation (15)

Download: PDF (965 KB)
Export: BibTeX | EndNote (RIS)

Abstract Determination of inorganic elements in traditional Chinese medicine by conventional wet-chemistry approach is complex and time-consuming. The samples must be digested before instrumental analysis. For preparations containing cinnabaris or realgar, high content of Hg and As will contaminate lab wares and instruments. However, X-ray fluorescence spectrometry is simple, fast and can simultaneously determine multiple elements in a non-destructive way. In this paper, portable X-ray fluorescence spectrometry was applied to establish a novel method for rapid and nondestructive determination of Hg and As in Niuhuang Qingxin Pills. And the method was employed in homogeneity analysis of the drug for the first time. After optimization of the measurement mode, using the inductively coupled plasma-optical emission spectroscopy as the reference value, working calibration curve was obtained for determination. Experiments results showed that precision was high with relative standard deviation of 0.09% and 0.23%, respectively, and the determination results of Hg and As were close to the reference values with relative mean deviations of 8.58% and 5.95%, respectively, which met the requirements of on-site rapid screening. Results indicated that contents of Hg in 2 batches of the samples were abnormally low and contents of As in 1 batches of the samples was abnormally high. Sample from 1 manufacturer was inhomogeneous. The proposed method was quick, simple, economic and environment-friendly, which offered a new approach for quality control of traditional Chinese medicine containing mineral. The portable instrument brings high efficiency and high throughput, which can help revealing hidden danger of drug quality. In all, X-ray fluorescence spectrometry can save time, manpower and resources, and has a bright prospect in application.

Key words：X-ray fluorescence spectrometry; Niuhuang Qingxin Pills (prescription of the Bureau); Mercury; Arsenic; Homogeneity

Received: 2016-04-05 Accepted: 2016-08-26

ZTFLH:

R284.1

Corresponding Authors: MA Shuang-cheng E-mail: masc@nifdc.org.cn

Cite this article:

URL:

https://www.gpxygpfx.com/EN/10.3964/j.issn.1000-0593(2017)10-3225-04 OR https://www.gpxygpfx.com/EN/Y2017/V37/I10/3225

[1] Chinese Pharmacopoeia Commission(国家药典委员会).Pharmacopoeia of the People’s Republic of China，Volume Ⅰ(中华人民共和国药典，一部). Beijing：China Medical Science and Technology Press (北京：中国医药科技出版社)，2015.
[2] WU Hui-bin，CHEN Zhi-cheng，WANG Xiao-yun，et al(吴辉彬，陈志成，王晓云，等). China Pharmaceuticals(中国药业)，2012，21(14)：44.
[3] DENG De-hong，ZHENG Jian-guo，ZHOU Zhao-hong，et al(邓德红，郑建国，周昭红，等). Asia-Pacific Traditional Medicine(亚太传统医药)，2016，12(6)：44.
[4] LIU Lan-sheng，YANG Hong，GAO Hai-yan，et al(刘兰生，杨泓，高海燕，等). Journal of North Pharmacy(北方药学)，2010，7(5)：3.
[5] ZHOU Yan-hong(周燕红). China Pharmacist(中国药师)，2015，18(12)：2193.
[6] LAN Chang-bo(蓝长波). Chinese Journal of Pharmaceutical Analysis(药物分析杂志)，2014，34(11)：2076.
[7] TIAN Hong-jun(田宏俊). Chinese Journal of Experimental Traditional Medical Formulae(中国实验方剂学杂志)，2012，18(16)：87.
[8] WU Wen-qi，XU Tao，HAO Qian，et al(吴文琪，许涛，郝茜，等). Metallurgical Analysis(冶金分析)，2011，31(3)：33.
[9] YIN Li-hui，LI Jun-qin，YU Hui，et al(尹利辉，李俊卿，俞辉，等). Chinese Journal of Pharmaceutical Analysis(药物分析杂志)，2012，32(7)：1124.
[10] XIE Lan-gui，WANG Jian，ZHAO Xia，et al(谢兰桂，王健，赵霞，等). Chinese Journal of Pharmaceutical Analysis(药物分析杂志)，2013，33(2)：286.
[11] ZHU Li，LIU Ming-li，YIN Li-hui，et al(朱俐，刘明理，尹利辉，等). Chinese Journal of Pharmaceutical Analysis(药物分析杂志)，2014，34(10)：1842.
[12] Chinese Pharmacopoeia Commission(国家药典委员会). Pharmacopoeia of the People’s Republic of China，Volume Ⅳ(中华人民共和国药典，四部). Beijing：China Medical Science and Technology Press (北京：中国医药科技出版社)，2015.