Indirect Protein Detection by Versatile SERS Sensors
CHEN Lei1, 2, LIU Mao-mao2, ZHANG Yong-jun2*, WANG Ya-xin2, HAN Xiao-xia3, ZHAO Bing3
1. Key Laboratory of Preparation and Application of Environmental Friendly Materials of Ministry of Education, Jilin Normal University, Changchun 130103, China
2. Key Laboratory of Functional Materials Physics and Chemistry of Ministry of Education, Jilin Normal University, Changchun 130103, China
3. State Key Laboratory of Supramolecular Structure and Meterials, Jilin University, Changchun 130012, China
Abstract：Proteins are essential for living organisms because they are main components of the physiological metabolic pathways of cells. As an ultrasensitive technique, surface-enhanced Raman scatting (SERS) has been proved having a great potential in high throughput biomolecules detection, especially in proteins detection. In this paper, recent advances of the development of SERS probe technology were presented, such as immunogold-based method, Raman-active nanomaterial-based sensors, enzymatic-based sensors, and reagent-based sensors.
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