Abstract：Oxygen saturation (SO2) for clinical observation of the disease changes provides a meaningful indicator. Traditional oxygen saturation analyses adopt the dual-wavelength and multi-wavelength photoplethysmography to achieve non-invasive detection to reduce the pain of patients. In this paper, a novel approach combining single wavelength laser optical absorption induced photoacoustic and optical scattering, was developed to noninvasively measure blood oxygen saturation, the concentration of deoxygenated haemoglobin (HbR) and oxyhemoglobin (HbO2). A theoretical derivation between the absorption and scattering light characteristics and linear relationship of photoacoustic spectroscopy built the single-wavelength oxygen saturation detection technology, so parameters analysis and imaging of tissue could also be obtained. Here, the phantom experiment successfully demonstrated the quantization of the concentration of a dual-ink combined with green-red ink imitating a blood with hemoglobin and oxygenated hemoglobin. The proportion of red ink, that is to say, pseudo-SO2 was measured with experimental errorless than 6.97%. Then the pseudo-SO2 was imaged in the single tube cross-section for blood vessel copy. Unlike conventional multi-wavelength photoacoustic or near infrared spectroscopy approaches, the proposed single-wavelength method significantly lowers the cost of laser system and portable implementations.
Key words：Photoacoustic image; Single wavelength; Scattered light; Statistics
基金资助: Project Supported by National Natural Science Foundation of China (81370350), Project Supported by Sichuan Provincial Department of Science and Technology (2012JY0089)
通讯作者:
高 博
E-mail: gaobo@scu.edu.cn
作者简介: MA Yao, (1979—), Lecturer, College of Physical Science and Technology, Sichuan University e-mail:
mayao@scu.edu.cn
引用本文:
马 瑶，高 博，陈 昶，赵 新，钱 正，龚 敏. 单波长光声光谱血氧饱和度检测技术研究[J]. 光谱学与光谱分析, 2017, 37(08): 2652-2656.
MA Yao, GAO Bo, CHEN Chang, ZHAO Xin, QIAN Zheng, GONG Min. Single-Wavelength Oxygen Saturation Detection Fusing Optical Absorption and Scattering Properties: A Phantom Study. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2017, 37(08): 2652-2656.
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