Surface Enhanced Raman Spectroscopy Study of D-Carnitine on a New Base
CHENG Hong-mei, ZHOU Guang-ming*, LI Jun-ping, ZHANG Cai-hong
Key Laboratory on Luminescence and Real-Time Analysis(Southwest University), Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China
Abstract：A fast and efficient way to synthesize a large number of silver nanowires was developed in this paper, in which the reaction conditions were optimized. Under the protection of Cu(NO3)2 silver nitrate was reduced by polyol with polyvinyl pyrrolidone (PVP) in existence. The silver nanowires with uniform structure and good dispersion were obtained. Surface enhancement activity of the silver nanowires was detected by using RhB as a probe molecule，its surface enhancement factor can reach 6.4×105. The results showed that the nanowires significantly enhance the Raman spectroscopy of RhB. The normal Raman spectroscopy (NRS), Raman spectroscopy of D-carnitine solution and Surface enhanced Raman Spectroscopy of D-carnitine by means of the new base were obtained. There are obvious Raman peaks at 3 100～2 800 and 1 700～200 cm-1, and the peak of 1 700～200 cm-1 in the surface enhanced Raman spectra of the D-carnitine can be obviously enhanced. The analysis showed that the angle between the molecular and silver nanoparticles were 180°. The vibrational peaks were assigned comprehensively. Compared with the NRS and SERS of D-carnitine, the detailed structural information of D-carnitine was obtained. In this paper, the surface enhanced Raman spectra of the D-carnitine absorbed on the synthesized silver nanoparticles were obtained, and the minimum detection concentration was 10-6 mol·L-1. The new method can be a rapid and characteristic way to detect D-carnitine, and it will also provide an important guidance for the studies on pharmacology of D-carnitine.
程洪梅，周光明*，李俊平，张彩红. 一种新型基底上右旋肉碱的表面增强拉曼光谱研究[J]. 光谱学与光谱分析, 2016, 36(06): 1755-1760.
CHENG Hong-mei, ZHOU Guang-ming*, LI Jun-ping, ZHANG Cai-hong. Surface Enhanced Raman Spectroscopy Study of D-Carnitine on a New Base. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2016, 36(06): 1755-1760.
[1] Fang H, Wu Huiqin，Huang Xiaolan, et al. Chinese Journal of Analysis Laboratory, 2014, 33(9): 1101. [2] Wong G K, Crawford M W. Anesthesiology, 2011, 114(6): 1417. [3] Mohamed M, Sayed-Ahmed, Amal Q, et al. Oxidative Medicine and Cellular Longevity, 2010, 3(4): 266. [4] Fatani Amal G, Darweesh Amal Q, Rizwan Lubna, et al. Chemotherapy, 2010, 56(1)： 71. [5] Molfino Alessio，Amabile Maria Ida，Monti Massimo，et al. International Journal of Cardiology, 2015, 1. [6] Minkler Paul E，Stoll，et al. Analytical Chemistry, 2015, 87(17): 8994. [7] Pesek Joseph J，Matyska Maria T. Journal of Chromatography A, 2015, 1401: 69. [8] Sánchez-Hernández L, María Castro-Puyana, Carmen García-Ruiz, et al. Food Chemistry, 2010, 120: 921. [9] Laura Sánchez-Hernández, Carmen García-Ruiz, Antonio L Crego, et al . Journal of Pharmaceutical and Biomedical Analysis, 2010, 53: 1217. [10] Gu Shuhua, Li Qingyi, Wang Xuecheng. US Patent, 2014, US 8, 709, 819B2: 436. [11] Zhao Longshan，Xiong Zhili，Lu Xiumei，et al. Plos One, 2015, 10: 6. [12] Magiera Sylwia, Baranowski Jacek. Journal of Pharmaceutical and Biomedical Analysis, 2015, 109: 171. [13] Hu Pingping, Liu Hui, Zhen Shujun, et al. Biosensors& Bioelectronics, 2015, 73: 228. [14] Tian Shu, Zhou Qun, Li Chuanhong, et al. J. Phys. Chem. C, 2013, 117:556. [15] Zhang Li, Wang Bin, Zhu Guang, et al. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 133: 411. [16] Merve Selen Akin, a Mehmet Yilmaz, a Esra Babur, et al. J. Mater. Chem. B, 2014, 2: 4894. [17] Ma Jingjing, Zhan Maosheng. RSC Adv., 2014, 4: 21060. [18] Benjamin Wiley, Sun Yugang, Xia Younan. Langmuir, 2005, 21: 8077. [19] Zhang T, Zhang L, Yang S, et al. Rare Metal Materials & Engineering, 2007, 36(10): 1844. [20] Zhao Y, Li Y, Li X, et al. Nanoscale, 2014, 6(19): 11112. [21] Prezgot Daniel, Lanoul Anatoli. Journal of Physical Chemistry C, 2015, 119(6): 3293.
