Development and Application of Six-Channel Fiber Optic Sensing Drug Dissolution Monitor
YAO Jun1, SHEN Jing2*, LI Li1*, LI Xin-xia1, CHEN Jian1
1. College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China 2. Department of Pharmacy, The Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China
Abstract：The drug dissolution test is an important examination of drug testing, which plays a very important role in the drug quality assessment. Automation and proceduring monitoring of drug dissolution can be implemented by the optical fiber sensing technology. Two modes of detection of UV-Vis absorption and fluorescence quenching were established by software implementation, with xenon lamp, deuterium lamp or halogen tungsten lamp as fluorescence, UV and visible light source, branch Y type optical fiber as light path transmission medium, UV-Vis probe and fluorescence molecular probe as light response devices, and CCD as detector. Optical fiber sensing drug dissolution monitor not only solves the current problems of time-consuming, and sampling of off-line analysis, but also provides real-time information of drug dissolution process. Thus, our study may provide a better evaluation method for the drug quality control.
Key words：Drug dissolution;Fiber optic sensing;Process monitoring;Quality control
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