Analysis of EDS Fingerprint Spectra of Mineral Drug Montmorillonite Powder Relying on Dual Index Grade Sequence Individualized Pattern Recognition Method and their Quickly Quality Evaluation
ZOU Hua-bin1, Ayiguzaili·Ablimiti1, ZHAI Hong2
1. School of Chemistry and Chemical Engineering of Shandong University (Center Campus), Ji’nan 250100, China 2. Information Network Center of Shandong Provincial Hospital Affiliated to Shandong University, Ji’nan 250021, China
Abstract：EDS(energy dispersive spectrometer)element fingerprint spectra is able to quickly measure the kinds and the contents of elements in any mineral drug. In dual index grade sequence individualized pattern recognition method, common (quantity) index and variation (quantity) index ratios of any two samples’ fingerprint spectra are calculated, and the individualized dual index sequence of each sample is constructed relying on its own EDS fingerprint spectra as the reference. Then the mean common (quantity) index ratio and the standard deviation S of all samples in each sample’s individualized dual index sequence are computed. On this basis, for each sample, its own similarity scale function P≥+xS is built up. By this function, the optimum x suitable for optimized classification/cluster of all samples is determined, and the individualized characteristics sequence of one sample, to which samples in the individualized characteristics sequence are significantly similar, is decided also. Finally, depending on these individualized characteristics sequences, the optimized classification/cluster of all samples can be carried out perfectly without any prior knowledge related to them. This method is not only suitable for the quantitative analysis on fingerprint spectra being of only common peaks, but also fits for that being of both common and variant peaks. In this study, the EDS element fingerprint spectra of seven mineral drug montmorillonite powder samples from different companies were detected. Then common (quantity) index and variant (quantity) index ratios of peak area (or contents of majorly active element Fe，Al，Ca，Mg，Si) among different EDS fingerprint spectra were obtained. In the similarity scale function P≥+xS, when x=0.5, these seven mineral drug montmorillonite powder samples could be quickly identified with high resolution, be classified into two groups, and their quality could be evaluated precisely. In general EDS element fingerprint spectra combined with dual index grade sequence individualized pattern recognition method offers a novel approach to quickly identifying mineral drugs with high resolution and for accurately quantitative quality evaluation of them，based on atomic content information provide by EDS fingerprint spectra.
邹华彬1 ，阿依古再丽·阿不力米提1 ，翟 红2 . 矿物药蒙脱石散EDS指纹图谱双指标等级序列个性化模式识别分析及快速质量评价 [J]. 光谱学与光谱分析, 2013, 33(12): 3321-3325.
ZOU Hua-bin1, Ayiguzaili·Ablimiti1, ZHAI Hong2 . Analysis of EDS Fingerprint Spectra of Mineral Drug Montmorillonite Powder Relying on Dual Index Grade Sequence Individualized Pattern Recognition Method and their Quickly Quality Evaluation . SPECTROSCOPY AND SPECTRAL ANALYSIS, 2013, 33(12): 3321-3325.
[1] LIU Jin(刘 劲). Medicine And Health Care(医药与保健), 2009，17(3): 72. [2] LU Lin, XU Jian-guo(卢 琳，徐建国). Xinjiang Journal of Traditional Chinese Medicine(新疆中医药), 2006，24(4): 93. [3] WANG Xian-hao, GU Hui (王贤浩，顾 辉). Journal of Chinese Electron Microscopy Society(电子显微学报), 2009, 28(4): 318. [4] ZOU Hua-bin, YUAN Jiu-rong, Lü Qing-tao, et al. ( 邹华彬, 袁久荣, 吕清涛，等). J. of Chinese Medicinal Materials(中药材), 2003, 26(9): 625. [5] LIU Yuan，MENG Qing-yan，PENG Lian-xin，et al(刘 圆，孟庆艳，彭镰心，等). Chin. J. Pharm. Anal.(药物分析杂志)，2007，27(8): 1182. [6] REN Chao-qin, LIU Yuan, YUAN Wei, et al(任朝琴, 刘 圆, 袁 玮, 等). Journal of Chengdu Medical College(成都医学院学报), 2009, 4(1): 7. [7] CHENG Yun-qing，LIU Jian-feng，LIU Qiang，et al(程云清，刘剑锋，刘 强，等). Journal of Nanjing Agricultural University(南京农业大学学报), 2011, 34(5): 155. [8] SHI Yun，TAN Xian-he, CHI Yu-mei, et al(石 芸，谈献和，池玉梅，等). Chinese Wild Plant Resources(中国野生植物资源), 2012，31(2): 29. [9] DING Ling, MENG Qing-yan, LIU Yuan(丁 玲, 孟庆艳, 刘 圆). Journal of Southwest University for Nationalities·Natural Science Edition(西南民族大学学报·自然科学版), 2012, 38(1): 77. [10] HUANG Li-ping，WU Jing(黄丽萍，吴 静). China Journal of Chinese Materia Medica(中国中药杂志), 2011，36(11): 1441. [11] ZOU Hua-bin(邹华彬). Chinese Traditional Patent Medicine(中成药), 2012, 34(4): 714. [12] ZOU Hua-bin，ZHANG Xin-ling，ZHAI Hong，et al(邹华彬，张新玲，翟 红, 等). China Journal of Chinese Materia Medica(中国中药杂志), 2008, 33(13): 1543. [13] ZOU Hua-bin, WANG Li-shuang, ZHAI Hong(邹华彬, 王丽双, 翟 红). Journal of Shandong University·Engineering Science(山东大学学报·工学版), 2012，42(4)：114.
